Fungicidal spiroheterocyclic derivatives

ABSTRACT

New fungicidal spiroheterocyclic compounds are described, having the general formula I, ##STR1## or an acid-addition salt thereof, in which R 1  or each R 1  independently represents an optionally substituted alkyl, cycloalkyl, cycloalkylalkyl, alkoxy, cycloalkoxy, alkoxyalkyl, aralkyl, aryl or aryloxy group, or R 1  or each R 1 , together with the ring to which they are attached, represents an optionally substituted polycyclic hydrocarbyl group, 
     R 2  represents a hydrogen atom or a C 1-4  alkyl group, 
     R 3  represents a hydrogen atom, a hydroxy group or an optionally substituted alkoxy or acyloxy group, 
     R 4  and R 5  each independently represent a hydrogen atom, an optionally substituted alkyl, alkenyl, alkynyl, cycloalkylalkyl, cycloalkyl, bicycloalkyl, tricycloalkyl, alkoxyalkyl, aryl, aralkyl, haloaralkyl, a 4- to 6- membered heterocyclyl, tetrahydrofurfuryl or dioxolanyl group, or R 4  and R 5  together represent an optionally substituted, saturated or unsaturated carbon chain which may optionally contain one or more oxygen atoms and which may optionally be aryl- or cycloalkyl-fused, 
     m represents zero or an integer from 1 to 6, and 
     p represents zero or an integer from 1 to 3. 
     The invention further relates to the preparation of the above spiroheterocyclic compounds, intermediates prepared during the synthesis of these compounds, compositions containing the compounds and their use as fungicides in the control of phytopathogenic fungi.

The present invention relates to certain new spiroheterocyclic compounds having fungicidal properties, processes for the preparation of these compounds, fungicidal compositions containing the compounds and the use of the compounds as fungicides for the control of phytopathogenic fungi.

In EP 281842, EP 349247, EP 413223 and WO 92/16518 fungicidal spiroheterocyclic compounds have been described. These known compounds contain a substituted cyclohexyl ring in spiro conjunction with a substituted heterocyclic five or six membered ring. The substituents of the cyclohexyl ring are usually (substituted) (branched) alkyl or phenyl groups. The substituents of the heterocyclic ring are usually (substituted) (cyclo)alkyl- or dialkyl-amino-methyl or dialkyl-amino-polymethyl groups, including alkylene-aminomethyl or alkylene-amino-polymethyl groups.

It has now been found that certain new spiroheterocyclic compounds show excellent fungicidal activity against certain phytopathogenic fungi, for instance against Plasmopora viticola, Botrytis cinera, Erysiphe graminis, Pseudocercosporella herpotrichoides, Rhizoctonia solani, Venturia inaequalis and Alternaria solani.

The present invention therefore relates to compounds of the general formula I ##STR2## or an acid-addition salt thereof, in which R¹ or each R¹ independently represents an optionally substituted alkyl, cycloalkyl, cycloalkylalkyl, alkoxy, cycloalkoxy, alkoxyalkyl, aralkyl, aryl or aryloxy group, or R¹ or each R¹, together with the ring to which they are attached, represents an optionally substituted polycyclic hydrocarbyl group,

R² represents a hydrogen atom or a C₁₋₄ alkyl group,

R³ represents a hydrogen atom, a hydroxy group or an optionally substituted alkoxy or acyloxy group,

R⁴ and R⁵ each independently represent a hydrogen atom, an optionally substituted alkyl, alkenyl, alkynyl, cycloalkylalkyl, cycloalkyl, bicycloalkyl, tricycloalkyl, alkoxyalkyl, aryl, aralkyl, haloaralkyl, a 4- to 6-member heterocyclyl, tetrahydrofurfuryl or dioxolanyl group, or R⁴ and R⁵ together represent an optionally substituted, saturated or unsaturated carbon chain which may optionally contain one or more oxygen atoms and which may optionally be aryl- or cycloalkyl-fused,

m represents zero or an integer from 1 to 6, and

p represents zero or an integer from 1 to 3.

The invention especially relates to compounds of the general formula I in which any alkyl part of any of the groups R¹ to R⁵ contains up to 12 carbon atoms, preferably up to 10 carbon atoms, more preferably up to 9 carbon atoms, any alkenyl or alkynyl part of any of the substituents R¹ to R⁵ contains up to 12 carbon atoms, preferably up to 10 carbon atoms, more preferably up to 8 carbon atoms, any cycloalkyl part of any of the substituents R¹ to R⁵ contains from 3 to 10 carbon atoms, preferably from 3 to 8 carbon atoms, more preferably from 3 to 6 carbon atoms, any bicyclic, tricyclic or polycyclic part of the groups R¹ to R⁵ contains from 6 to 12, from 8-14, respectively from 6 to 20 carbon atoms, any saturated or unsaturated chain, especially carbon chain, contains from 3 to 10 chain members, preferably from 4 to 6 carbon atoms, and any aryl part of any of the substituents R¹ to R⁵ contains 6, 10 or 14 carbon atoms, preferably 6 or 10 carbon atoms, and in which each optionally substituted group independently is substituted by one or more halogen atoms or nitro, cyano, alkyl, preferably C₁₋₆ alkyl, cycloalkyl, preferably C₃₋₆ cycloalkyl, cycloalkenyl, preferably C₃₋₆ cycloalkenyl, haloalkyl, preferably C₁₋₆ haloalkyl, halocycloalkyl, preferably C₃₋₆ halocycloalkyl, alkoxy, preferably C₁₋₆ alkoxy, haloalkoxy, preferably C₁₋₆ haloalkoxy, phenyl, halo- or dihalo-phenyl or pyridyl groups. Any alkyl, alkenyl or alkynyl group may be linear or branched. A 4- to 6-membered heterocyclic group may be any heterocyclic group with 4 to 6 ring atoms, interrupted by one or more heteroatoms selected from sulfur, nitrogen, and oxygen, preferably oxygen. A halogen atom suitably denotes a fluorine, chlorine or bromine atom.

The invention especially relates to compounds of the general formula I in which R¹ or each R¹ independently represents a C₁₋₁₀ alkyl, C₃₋₆ cycloalkyl, C₃₋₈ cycloalkyl-C₁₋₆ alkyl, C₁₋₆ alkoxy, C₁₋₁₀ alkoxy-C₁₋₆ alkyl or phenyl group, or one or more groups R¹ together with the ring to which they are attached, represent a C₇₋₂₀ polycyclic group, preferably a C₈₋₁₂ bicyclic, C₉₋₁₄ tricyclic or C₉₋₁₆ quadricyclic hydrocarbyl group, preferably a saturated hydrocarbyl group, each of the above groups optionally substituted by one or more halogen atoms, especially chlorine and/or fluorine atoms, or C₁₋₄ alkyl, C₁₋₄ haloalkyl or C₁₋₄ alkoxy groups. Preferably R¹ or each R¹ independently represents a C₁₋₈, suitably C₁₋₆, alkyl group, especially a branched alkyl group, more especially secondary and tertiary alkyl groups as secondary butyl, tertiary butyl and tertiary amyl groups. More preferably, R¹ or each R¹ independently represents a t-butyl or t-amyl group. The invention also especially relates to compounds of the general formula I in which m represents an integer from 1 to 4, preferably 1 or 2, more preferably 1. The group or groups R¹ are preferably attached to the positions 3, 4 and/or 5 of the cyclohexyl ring, more preferably to the 4-position.

The invention also especially relates to compounds of the general formula I in which R² represents a hydrogen atom or a methyl group, preferably a hydrogen atom.

The invention further especially relates to compounds of the general formula I in which R³ represents a hydrogen atom.

The invention further especially relates to compounds of the general formula I in which R⁴ and R⁵ each independently represent a hydrogen atom, a C₁₋₂₀ alkyl, especially C₃₋₁₀ alkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₃₋₈ cycloalkyl-C₁₋₆ alkyl, C₃₋₈ cycloalkyl, C₆₋₁₀ bicycloalkyl, C₈₋₁₄ tricycloalkyl, phenyl, phenyl-C₁₋₆ alkyl, especially benzyl, halophenyl-C₁₋₆ alkyl or pyridyl-C₁₋₆ alkyl group, or R⁴ and R⁵ together represent a saturated carbon chain containing three to eight carbon atoms while optionally one or more additional oxygen atoms may be present in the chain and which chain may optionally be aryl- or cycloalkyl-fused. Preferably R⁴ and R⁵ each independently represent a hydrogen atom, a C₂ -C₁₂ alkyl, C₂₋₅ alkenyl, C₅₋₇ cyclo-C₁₋₂ alkyl, C₅₋₇ cycloalkyl, C₈₋₁₀ bicycloalkyl or phenyl-C₁₋₂ alkyl group, or R⁴ and R⁵ together represent a saturated chain containing four or five carbon atoms while optionally additional oxygen atoms may be present and which chain optionally may be aryl- or cycloalkyl-fused, especially cyclopentyl, cyclohexyl or cycloheptyl fused, each of the above groups optionally substituted by one or more halogen atoms, especially chlorine and/or fluorine atoms, or C₁₋₄ alkyl, C₁₋₄ haloalkyl, C₄₋₆ cycloalkenyl or C₁₋₄ alkoxy groups.

The invention especially relates to compounds of the general formula I in which p represents 0, 1 or 2.

A particular preferred sub-group of compounds of the general formula I is that in which R¹ represents a butyl, pentyl or phenyl group, especially a t-butyl or t-pentyl group. Another particular sub-group is that in which R² represents a hydrogen atom. Another particular sub-group is that in which R³ represents a hydrogen atom. Yet another particular sub-groups is that in which R⁴ and R⁵ each independently represent a hydrogen atom or a linear or branched C₁₋₁₇ alkyl group, especially a C₁₋₁₀ alkyl group, an allyl, C₃₋₇ cycloalkyl optionally fused with a cyclohexyl group, benzyl or phenyl group, or R⁴ and R⁵ together represent a saturated C₄₋₇ carbon chain, especially a C₄₋₆ carbon chain, which optionally may contain an additional oxygen atom and which optionally may be fused with a cyclohexyl ring, each of the above groups optionally substituted by a fluorine, chlorine or bromine atom or one or two methyl groups, a t-butyl, cyclohexyl, cyclohexenyl, phenyl or pyridyl group.

The present invention further provides a process for the preparation of compounds of the general formula I as defined hereinbefore or acid-addition salts thereof, in which R³ represents a hydrogen atom and p represents zero, which process comprises reaction of a compound of the general formula II ##STR3## in which R¹ and m are as defined hereinbefore, with a compound of the general formula III ##STR4## in which R⁴ and R⁵ are as defined hereinbefore, under reducing conditions.

Suitable reducing conditions for the reductive amination are well known in the literature. See for instance J. March, Advanced Organic Chemistry, J. Whiley & Sons, New York, 1985. Suitable reducing agents are formic acid (Leuckart-Wallach reduction), complex metal hydrides such as cyanoboro hydride and hydrogen gas together with a hydrogenation catalyst, e.g. Raney nickel.

Some of the starting compounds II are known in the literature. See for instance Bull. Chim. Soc. France, 1958, 211 and Bull. Chim. Soc. France, 1974 (12), 2889-2891. New starting compounds of the general formula II, which form a feature of the invention, may be prepared in the same way as the known compounds as discussed before.

Starting compounds of the general formula III are well known in the literature, and many of them are commercially available.

The reductive amination process of the present invention is suitably carried out in the presence of an organic solvent, for example an ether, an alcohol or a carboxylic acid such as acetic acid.

The process is suitably carried out at a temperature in the range of 0° to 150° C., especially between 40° and 120° C., in the case of formic acid as reducing agent or at temperatures between 0° and 50° C. in the case of complex borohydrides as reducing agents.

In an alternative process for the preparation of the compounds of the present invention the starting compound II is first converted into the corresponding 3-amino-1-oxaspiro(4,5)decane compound, for instance by reaction with hydroxylamine followed by reduction of the obtained oxime. The 3-amino compound is thereafter alkylated, especially with a ketone or aldehyde under suitable reducing conditions or with an alkylating agent. The reaction of the ketone starting material and hydroxylamine is well known in the literature. The reaction may be carried out in an organic solvent/water mixture at temperature between 20° and 100° C. The reduction of the oxime compounds is also well known in the literature. The reduction can be carried out with complex metal hydrides, for instance lithium aluminium hydride, in an organic solvent, e.g. tetrahydrofuran, at temperatures between 40° and 80° C. The alkylation of amines using ketones or aldehydes is well known in the literature, and is described hereinbefore. The alkylation using alkylating agents is also well known in the literature. Alkylating agents, for instance (substituted) alkyl halides may be used in suitable, inert organic solvents at temperatures between 40° and 100° C.

The present invention also provides a process for the preparation of compounds of the general formula I as defined hereinbefore, or acid addition salts thereof, and in which R³ represents a hydroxy, an alkoxy or an acyloxy group and p represents 1, which process comprises reaction of a compound of the general formula II as defined hereinbefore, with hydrogen cyanide or a salt thereof, followed by reduction of the obtained cyanohydrine and alkylation, especially with a ketone or aldehyde under suitable reducing conditions or an alkylating reagent, optionally followed by alkylation or acylation of the 3-hydroxy group. The reaction of the ketone starting material and hydrogen cyanide or a salt thereof can be carried out according to methods well known in the literature, for instance by reaction with sodium- or potassium cyanide at temperatures between 0° and 100° C., especially ambient temperature, in an organic solvent as an alcohol. The reduction of cyanohydrines is also well known in the literature, and can be performed using hydrogen and a noble metal catalyst, e.g. platinum or palladium. The alkylation of the 3-aminomethyl group may be carried out as described hereinbefore. Alkylation and acylation of the 3-hydroxy group can be done as described in the literature for the alkylation or acylation of tertiary alcohols.

The present invention also provides a process for the preparation of compounds of the general formula I as defined hereinbefore, or acid addition salts thereof, and in which R³ represents a hydrogen atom and p represents 1, which process comprises reduction of a compound of the general formula II as defined hereinbefore to an alcohol, activation of the alcohol, followed by reaction with hydrogen cyanide or a salt thereof, reduction of the cyanide group and alkylation of the amine obtained, especially with a ketone or aldehyde under suitable reducing conditions or an alkylating reagent. The reduction of the carbonyl group of the starting compound of the general formula II can be carried out according to methods well known in the literature, for instance by reduction with a complex metal hydride such as sodium borohydride. The activation of the alcohol is also well described in the literature, and may be carried out by reaction with a sulfonylchloride. The substitution of the activated hydroxy group is suitably carried out in a polar organic solvent, for instance an alcohol, an ether or a ketone, using hydrogen cyanide or a salt thereof. The reduction of the cyano group and the alkylation thereof can be carried out as described hereinbefore.

The present invention also provides a process for the preparation of a compound of the general formula I as defined hereinbefore, or acid addition salts thereof, and in which R³ represent a hydrogen atom and p represents 2, which process comprises reaction of a compound of the general formula II as defined hereinbefore, with cyanoacetic acid followed by reduction of the compound obtained into an amine, and alkylation of the amine, especially with a ketone or aldehyde under suitable reducing conditions or an alkylating agent. The reaction of the ketone starting material and cyanoacetic acid is suitably carried out in a polar organic solvent such as pyridine. The reduction of the cyano group and the alkylation of the 3-aminoethyl group may be carried out as described hereinbefore.

Suitably all reactions are carried out using substantially equimolar amounts of the reactants. However, it can be expedient to use one reactant in excess.

It will be appreciated that in addition to the above described reaction steps additional chemical modifications can be made to the compounds and intermediates, e.g. introduction or amendment of certain substituents, additional alkylation reactions etc.

The invention also provides fungicidal compositions comprising at least one of the compounds according to general formula I or an acid addition salt thereof, as well as methods of combating fungi at a locus comprising treatment of the locus with a compound of formula I or an acid addition salt thereof as defined hereinbefore, or with a composition as defined in this specification. The locus to be treated especially comprises plants subject to or subjected to fungal attack, seeds of such plants or the medium in which the plants are growing or are to be grown.

The fungicidal composition comprises a carrier and, as active ingredient, a compound of the general formula I or an acid addition salt thereof.

A method of making such a composition is also provided, which comprises bringing a compound of the general formula I as defined above or an acid addition salt thereof into association with at least one carrier. Such a composition may contain a single compound or a mixture of several compounds of the present invention. It is also envisaged that different isomers or mixtures of isomers may have different levels or spectra of activity and thus compositions may comprise individual isomers or mixtures of isomers.

The invention further relates to the use as a fungicide of a compound of formula I as defined hereinbefore or a composition as defined hereinbefore.

A composition according to the invention preferably contains from 0.5 to 95% by weight of active ingredient.

A carrier in a composition according to the invention is any material with which the active ingredient is formulated to facilitate application to the locus to be treated, which may for example be a plant, seed or soil, or to facilitate storage, transport or handling. A carrier may be a solid or a liquid, including a material which is normally gaseous but which has been compressed to form a liquid, and any of the carriers normally used in formulating fungicidal compositions may be used.

Suitable solid carriers include natural and synthetic clays and silicates, for example natural silicas such as diatomaceous earths; magnesium silicates, for example talcs; magnesium aluminium silicates, for example attapulgites and vermiculites; aluminium silicates, for example kaolinites, montmorillonites and micas; calcium carbonate; calcium sulphate; ammonium sulphate; synthetic hydrated silicon oxides and synthetic calcium or aluminium silicates; elements, for example carbon and sulphur; natural and synthetic resins, for example coumarone resins, polyvinyl chloride, and styrene polymers and copolymers; solid polychlorophenols; bitumen; waxes, for example beeswax, paraffin wax, and chlorinated mineral waxes; and solid fertilisers, for example superphosphates.

Suitable liquid carriers include water; alcohols, for example isopropanol and glycols; ketones, for example acetone, methyl ethyl ketone, methyl isobutyl ketone and cyclohexanone; ethers; aromatic or araliphatic hydrocarbons, for example benzene, toluene and xylene; petroleum fractions, for example, kerosine and light mineral oils; chlorinated hydrocarbons, for example carbon tetrachloride, perchloroethylene and trichloroethane. Mixtures of different liquids are often suitable.

Fungicidal compositions are often formulated and transported in a concentrated form which is subsequently diluted by the user before application. The presence of small amounts of a carrier which is a surface-active agent facilitates this process of dilution. Thus preferably at least one carrier in a composition according to the invention is a surface-active agent. For example the composition may contain at least two carriers, at least one of which is a surface-active agent.

A surface-active agent may be an emulsifying agent, a dispersing agent or a wetting agent; it may be nonionic or ionic. Examples of suitable surface-active agents include the sodium or calcium salts of polyacrylic acids and lignin sulphonic acids; the condensation products of fatty acids or aliphatic amines or amides containing at least 12 carbon atoms in the molecule with ethylene oxide and/or propylene oxide; fatty acid esters of glycerol, sorbitol, sucrose or pentaerythritol; condensates of these with ethylene oxide and/or propylene oxide; condensation products of fatty alcohol or alkyl phenols, for example p-octylphenol or p-octylcresol, with ethylene oxide and/or propylene oxide; sulphates or sulphonates of these condensation products; alkali or alkaline earth metal salts, preferably sodium salts, of sulphuric or sulphonic acid esters containing at least 10 carbon atoms in the molecule, for example sodium lauryl sulphate, sodium secondary alkyl sulphates, sodium salts of sulphonated castor oil, and sodium alkylaryl sulphonates such as dodecylbenzene sulphonate; and polymers of ethylene oxide and copolymers of ethylene oxide and propylene oxide.

The compositions of the invention may for example be formulated as wettable powders, dusts, granules, solutions, emulsifiable concentrates, emulsions, suspension concentrates and aerosols. Wettable powders usually contain 25, 50 or 75% w of active ingredient and usually contain in addition to solid inert carrier, 3-10% w of a dispersing agent and, where necessary, 0-10% w of stabiliser(s) and/or other additives such as penetrants or stickers. Dusts are usually formulated as a dust concentrate having a similar composition to that of a wettable powder but without a dispersant, and may be diluted in the field with further solid carrier to give a composition usually containing 1/2-10% w of active ingredient. Granules are usually prepared to have a size between 10 and 100 BS mesh (1.676-0.152 mm), and may be manufactured by agglomeration or impregnation techniques. Generally, granules will contain 1/2-75% w active ingredient and 0-10% w of additives such as stabilisers, surfactants, slow release modifiers and binding agents. The so-called "dry flowable powders" consist of relatively small granules having a relatively high concentration of active ingredient. Emulsifiable concentrates usually contain, in addition to a solvent and, when necessary, co-solvent, 1-50% w/v active ingredient, 2-20% w/v emulsifiers and 0-20% w/v of other additives such as stabilisers, penetrants and corrosion inhibitors. Suspension concentrates are usually compounded so as to obtain a stable, non-sedimenting flowable product and usually contain 10-75% w active ingredient, 0.5-15% w of dispersing agents, 0.1-10% w of suspending agents such as protective colloids and thixotropic agents, 0-10% w of other additives such as defoamers, corrosion inhibitors, stabilisers, penetrants and stickers, and water or an organic liquid in which the active ingredient is substantially insoluble; certain organic solids or inorganic salts may be present dissolved in the formulation to assist in preventing sedimentation or as anti-freeze agents for water.

Aqueous dispersions and emulsions, for example compositions obtained by diluting a wettable powder or a concentrate according to the invention with water, also lie within the scope of the invention. The said emulsions may be of the water-in-oil or of the oil-in-water type, and may have a thick `mayonnaise` like consistency.

The composition of the invention may also contain other ingredients, for example other compounds possessing herbicidal, insecticidal or fungicidal properties.

Of particular interest in enhancing the duration of the protective activity of the compounds of this invention is the use of a carrier which will provide a slow release of the fungicidal compounds into the environment of the plant which is to be protected. Such slow-release formulations could, for example, be inserted in the soil adjacent to the roots of a vine plant, or could include an adhesive component enabling them to be applied directly to the stem of a vine plant.

The present invention still further provides the use as a fungicide of a compound of the general formula I as defined above or a composition as defined above.

The present invention is of wide applicability in the protection of crop plants against fungal attack. Typical crops which may be protected include cereals, especially wheat and barley, rice, vines, potatoes, tomatoes, top fruit, especially apples, and cucumber. The duration of protection is normally dependent on the individual compound selected, and also a variety of external factors, such as climate, whose impact is normally mitigated by the use of a suitable formulation. The compounds of the present invention are especially suitable to combat Erysiphe graminis in cereals.

The invention is further illustrated by the following examples.

EXAMPLES 1-180

3-Amino-1-oxaspiro(4,5)decane derivatives

(i) Starting materials

1-Oxaspiro(4,5)decane-3-one and 8-t-butyl-1-oxaspiro(4,5)-decane-3-one were prepared as described in the literature (J. Cologne, R. Falcotet and R. Gaumont, Bull. Soc. Chim. France, 1958, 211 and P. Picard and J. Moulines, Bull Soc. Chim. France, 1974 (12), 2889). New substituted 1-oxaspiro(4.5)decane-3-ones were prepared according to the same method (8-phenyl-1-oxaspiro(4,5)-decane-3-one (m.p. 40°-65° C.; mixture of cis and trans diastereoisomer (4:1); ¹ H NMR (CDCl3): 4.02*(s,2H), 3.95(s,2H); 2.33*(s,2H); 2.25 (s, 2H); 1.90(m, 2H); 1.63-1.35(m, 6H); 1.25(dd, 2H); 1.10(m, 1H); 0.80(s, 9H); 0.77*(s, 9H); where signals are separated the minor (trans) diastereoisomer is indicated by an asterisk.); 8-(2-(2-methylbutyl))-1-oxaspiro(4,5)decane-3-one) (b.p. 80°-82° C./0.05 mbar; ¹ H NMR (CDCl₃) (cis isomer, obtained from the cis/trans mixture by crystallisation from light petroleum): 7.25(m,5H); 4.02(s,2H); 2.53(m, ¹ H); 2.34(s,2H); 2.07-1.55(m,8H); 6,8,10-(trimethylenemethane)-1-oxaspiro(4,5)decane-3-one (starting from adamantanone; m.p. 56°-57° C.)), 8-t-butyl-3-methyl-1-oxaspiro-(4,5)decane-3-one (b.p. 70°-80° C./0.04 mbar); 8-(2-(2,4,4-trimethyl-pentyl))-1-oxaspiro(4,5)decan-3-one (n_(D) ²² 1.4834) 8-(2-(2-cyclohexylpropyl))-1-oxaspiro(4,5)decane-3-one (m.p. 63°-69° C.).

(ii) Preparation of 3-Amino-1-oxaspiro(4,5)decane derivatives

The title compounds were prepared by dissolving the (substituted) 1-oxaspiro(4,5)decane-3-one (10 mmol), an amine (10.5 mmol) and zinc chloride (0.7 g, 5.2 mmol) in 25 ml dry methanol. Sodium cyano-borohydride (0.75 g, 12 mmol) was then added and the reaction mixture was stirred overnight. The solvent was distilled off in vacuo and the residue was taken up in ethylacetate (50 ml), washed with 1N sodium hydroxide (100 ml) and water (100 ml). The organic layer was dried with magnesium sulphate, filtered and the solvent was distilled off in vacuo. The resulting oil was purified by chromatography on silica with toluene/20% ethylacetate. Evaporation of the product containing fractions yield the desired compounds, usually in yields between 40 and 80%. In some cases Raney nickel and hydrogen were used, (compound 2: 8-t-butyl-1-oxaspiro(4,5)decane-3-one (10.5 g, 50 mmol) and n-hexylamine (5.5 g, 55 mmol) in methanol (50 ml) was hydrogenated on Raney Nickel (10.0 g, slurried with methanol) at 60° C. After hydrogen uptake had ceased the catalyst was filtered off and washed with methanol. Evaporation of the solvent and distillation of the residue (14.8 g) yielded compound No. 2 as a colourless oil (9.0 g). It was further purified by flash chromatography (silica, toluene/ethylacetate 1:1)).

Compounds according to the invention were prepared as detailed in Table 1 below. In this table, the compounds are identified by reference to formula I.

                                      TABLE I.sup.1,2                              __________________________________________________________________________      ##STR5##                                       I                              R.sup.1      R.sup.4   R.sup.5          ACID                                   __________________________________________________________________________      1                                                                             t-C.sub.4 H.sub.9                                                                           H         CH.sub.2 C.sub.6 H.sub.4 -.sub.4 -Cl                     2                                                                             t-C.sub.4 H.sub.9                                                                 H         (CH.sub.2).sub.5 CH.sub.3                                          3                                                                             t-C.sub.4 H.sub.9                                                                           CH.sub.2 CH(CH.sub.3)OCH(CH.sub.3)CH.sub.2                         4                                                                             t-C.sub.4 H.sub.9                                                                 CH.sub.2 CH.sub.2 CH(C.sub.6 H.sub.5)CH.sub.2 CH.sub.2                       5                                                                             t-C.sub.4 H.sub.9                                                                           H         (CH.sub.2).sub.6 CH.sub.3                                6                                                                             t-C.sub.4 H.sub.9                                                                           CH.sub.2 CH.sub.2 CH(CH.sub.2 ).sub.4 CHCH.sub.2                   7                                                                             t-C.sub.4 H.sub.9                                                                           H         (CH.sub.2).sub.7 CH.sub.3                                8                                                                             t-C.sub.4 H.sub.9                                                                 H         (CH.sub.2).sub.4 CH.sub.3                                          9                                                                             t-C.sub.4 H.sub.9                                                                           (CH.sub.2).sub.4                                                  10                                                                             t-C.sub.4 H.sub.9                                                                 (CH.sub.2).sub.5                                                            11                                                                             t-C.sub.4 H.sub.9                                                                 (CH.sub.2).sub.2 O(CH.sub.2).sub.2                                          12                                                                             t-C.sub.4 H.sub.9                                                                           (CH.sub.2).sub.3 CH.sub.3                                                                (CH.sub.2).sub.3 CH.sub.3                               13                                                                             t-C.sub.4 H.sub.9                                                                 (CH.sub.2).sub.2 CH.sub.3                                                                (CH.sub.2).sub.2 CH.sub.3                                         14                                                                             t-C.sub.4 H.sub.9                                                                 CH.sub.3  (CH.sub.2).sub.5 CH.sub.3                                         15                                                                             t-C.sub.4 H.sub.9                                                                           CH.sub.2 CH(CH.sub.3)CH.sub.2 CH(CH.sub.3)CH.sub.2                16                                                                             t-C.sub.4 H.sub.9                                                                           H         C.sub.6 H.sub.11                                        17                                                                             t-C.sub.4 H.sub.9                                                                           CH(CH.sub.3)(CH.sub.2).sub.4                                      18                                                                             t-C.sub.4 H.sub.9                                                                 CH.sub.2 CH(CH.sub.3)(CH.sub.2).sub.3                                       19                                                                             t-C.sub.4 H.sub.9                                                                 (CH.sub.2).sub.2 CH(CH.sub.3)(CH.sub.2).sub.2                               20                                                                             t-C.sub.4 H.sub.9                                                                           CH.sub.3  C.sub.6 H.sub.11                                        21                                                                             t-C.sub.4 H.sub.9                                                                           (CH.sub.2).sub.6                                                  22                                                                             t-C.sub.4 H.sub.9                                                                           H         C.sub.6 H.sub.5                                         23                                                                             t-C.sub.4 H.sub.9                                                                 H         C.sub.6 H.sub.4 -.sub.4 -Cl                                       24                                                                             t-C.sub.4 H.sub.9                                                                 H         C.sub.6 H.sub.4 -.sub.4 -t-C.sub.4 H.sub.9                        25                                                                             t-C.sub.4 H.sub.9                                                                 H         C.sub.6 H.sub.4 -.sub.4 -n-C.sub.4 H.sub.9                        26                                                                             t-C.sub.4 H.sub.9                                                                 H         CH.sub.2 C.sub.6 H.sub.4 -.sub.4 -C.sub.4 H.sub.9                 27                                                                             t-C.sub.4 H.sub.9                                                                 H         (CH.sub.2).sub.5 CH.sub.3                                         28                                                                             t-C.sub.4 H.sub.9                                                                 H         CH.sub.2 C.sub.6 H.sub.4 -.sub.4 -CH.sub.3                        29                                                                             t-C.sub.4 H.sub.9                                                                 H         CH.sub.2 C.sub.6 H.sub.4 -.sub.4 -Br                              30                                                                             t-C.sub.4 H.sub.9                                                                 H         CH.sub.2 C.sub.6 H.sub.4 -.sub.4 -F                               31                                                                             t-C.sub.4 H.sub.9                                                                 H         CH.sub.2 C.sub.6 H.sub.5                                          32 H         H         (CH.sub.2).sub.5 CH.sub.3                               33 H         H         CH.sub.2 C.sub.6 H.sub.5                                34 H         H         CH.sub.2 C.sub.6 H.sub.4 -.sub.4 -Cl                    35 H         (CH.sub.2).sub.5                                                  36 H         CH.sub.2 CH(CH.sub.3)OCH(CH.sub.3)CH.sub.2                        37                                                                             t-C.sub.4 H.sub.9                                                                           H         (CH.sub.2).sub.5 CH.sub.3.HCl                           38                                                                             t-C.sub.4 H.sub.9                                                                 H         (CH.sub.2).sub.5 CH.sub.3.p-toluene-                                                     sulphonic acid                                          39                                                                             t-C.sub.4 H.sub.9                                                                 H         (CH.sub.2).sub.5 CH.sub.3.benzoic                                                        acid                                                    40                                                                             t-C.sub.4 H.sub.9                                                                 H         (CH.sub.2).sub.5 CH.sub.3.saccharate                              41                                                                             t-C.sub.4 H.sub.9                                                                 H         (CH.sub.2).sub.5 CH.sub.3.acetate                                 42                                                                             t-C.sub.4 H.sub.9                                                                 H         (CH.sub.2).sub.9 CH.sub.3                                         43                                                                             t-C.sub.4 H.sub.9                                                                 H         (CH.sub.2).sub.11 CH.sub.3                                        44                                                                             t-C.sub.4 H.sub.9                                                                 H         (CH.sub.2).sub.13 CH.sub.3                                        45                                                                             t-C.sub.4 H.sub.9                                                                 H         (CH.sub.2).sub.15 CH.sub.3                                        46                                                                             t-C.sub.4 H.sub.9                                                                 H         (CH.sub.2).sub.17 CH.sub.3                                        47                                                                             t-C.sub.4 H.sub.9                                                                 H         CH.sub.2 -.sub.3 -C.sub.5 H.sub.4 N                               48                                                                             t-C.sub.4 H.sub.9                                                                 (CH.sub.2).sub.3 CH.sub.3                                                                CH.sub.2 -.sub.3 -C.sub.5 H.sub.4 N                               49                                                                             t-C.sub.5 H.sub.11                                                                H         (CH.sub.2).sub.4 CH.sub.3                                         50                                                                             t-C.sub.5 H.sub.11                                                                (CH.sub.2).sub.4 CH.sub.3                                                                (CH.sub.2).sub.4 CH.sub.3                                         51                                                                             t-C.sub.5 H.sub.11                                                                H         C.sub.6 H.sub.11                                                  52                                                                             t-C.sub.5 H.sub.11                                                                          CH.sub.2 CH(CH.sub.3)CH.sub.2 CH(CH.sub.3)CH.sub.2                53                                                                             t-C.sub.5 H.sub.11                                                                CH.sub.2 CH(CH.sub.3)OCH(CH.sub.3)CH.sub.2                                  54 C.sub.6 H.sub.5                                                                          H         (CH.sub.2).sub.4 CH.sub.3                               55 C.sub.6 H.sub.5                                                                          (CH.sub.2).sub.3 CH.sub.3                                                                (CH.sub.2).sub.3 CH.sub.3                               56 C.sub.6 H.sub.5                                                                          H         C.sub.6 H.sub.11                                        57 C.sub.6 H.sub.5                                                                          CH.sub.2 CH(CH.sub.3)CH.sub.2 CH(CH.sub.3)CH.sub.2                58 C.sub.6 H.sub.5                                                                          CH.sub.2 CH(CH.sub.3)OCH(CH.sub.3)CH.sub.2                        59 H         CH.sub.3  (CH.sub.2).sub.5 CH.sub.3                               60                                                                             t-C.sub.5 H.sub.11                                                                CH.sub.3  (CH.sub.2).sub.5 CH.sub.3                                         61 C.sub.6 H.sub.5                                                                          CH.sub.3  (CH.sub.2).sub.5 CH.sub.3                               62                                                                             t-C.sub.4 H.sub.9                                                                 H         (CH.sub.2).sub.2 CH.sub.3                                         63                                                                             t-C.sub.4 H.sub.9                                                                 H         CH(CH.sub.3).sub.2                                                64                                                                             t-C.sub.4 H.sub.9                                                                 H         (CH.sub.2).sub.3 CH.sub.3                                         65                                                                             t-C.sub.4 H.sub.9                                                                 H         CH(CH.sub.3)(C.sub.2 H.sub.5)                                     66                                                                             t-C.sub.4 H.sub.9                                                                 H         CH.sub.2 CH(CH.sub.3).sub.2                                       67                                                                             t-C.sub.4 H.sub.9                                                                 CH.sub.3  CH.sub.3                                                          68                                                                             t-C.sub.4 H.sub.9                                                                 C.sub.2 H.sub.5                                                                          C.sub.2 H.sub.5                                                   69                                                                             t-C.sub.4 H.sub.9                                                                 (CH.sub.2).sub.5 CH.sub.3                                                                (CH.sub.2).sub.5 CH.sub.3                                         70                                                                             t-C.sub.4 H.sub.9                                                                 H         C.sub.5 H.sub.9                                                   71                                                                             t-C.sub.4 H.sub.9                                                                 H         C.sub.3 H.sub.5                                                   72                                                                             t-C.sub.4 H.sub.9                                                                 C.sub.2 H.sub.5                                                                          (CH.sub.2).sub.4 CH.sub.3                                         73                                                                             t-C.sub.4 H.sub.9                                                                 (CH.sub.2).sub.2 CH.sub.3                                                                (CH.sub.2).sub.4 CH.sub.3                                         74                                                                             t-C.sub.4 H.sub.9                                                                 (CH.sub.2).sub.3 CH.sub.3                                                                (CH.sub.2).sub.4 CH.sub.3                                         75                                                                             t-C.sub.4 H.sub.9                                                                 CH.sub.2 CH(CH.sub.3).sub.2                                                              (CH.sub.2).sub.4 CH.sub.3                                         76                                                                             t-C.sub.4 H.sub.9                                                                 CH(CH.sub.3).sub.2                                                                       (CH.sub.2).sub.4 CH.sub.3                                         77                                                                             t-C.sub.4 H.sub.9                                                                 C.sub.6 H.sub.11                                                                         (CH.sub.2).sub.4 CH.sub.3                                         78                                                                             t-C.sub.4 H.sub.9                                                                 CH.sub.3  (CH.sub.2).sub.4 CH.sub.3                                         79                                                                             t-C.sub.4 H.sub.9                                                                 CH.sub.2 CHCH.sub.2                                                                      C.sub.6 H.sub.11                                                  80                                                                             t-C.sub.4 H.sub.9                                                                 CH.sub.3  C.sub.6 H.sub.11                                                  81                                                                             t-C.sub.4 H.sub.9                                                                 H                                                                           t-C.sub.4 H.sub.9                                                              82                                                                             t-C.sub.4 H.sub.9                                                                 H         CH.sub.2 C.sub.6 H.sub.11                                         83                                                                             t-C.sub.4 H.sub.9                                                                 H         CH(C.sub.2 H.sub.5).sub.2                                         84                                                                             t-C.sub.4 H.sub.9                                                                 H         (CH.sub.2).sub.5 CH.sub.3                                         2-CH.sub.3)            (+R.sup.2 =                                             85                                                                             t-C.sub.4 H.sub.9                                                                 H                                                                           2-norbornyl                                                                    86                                                                             t-C.sub.4 H.sub.9                                                                 H                                                                           2-adamantyl                                                                    87                                                                             t-C.sub.4 H.sub.9                                                                 H         (2-CH.sub.3)C.sub.6 H.sub.10                                      88                                                                             t-C.sub.4 H.sub.9                                                                 H         (3-CH.sub.3)C.sub.6 H.sub.10                                      89                                                                             t-C.sub.4 H.sub.9                                                                 H         (4-CH.sub.3)C.sub.6 H.sub.10                                      90                                                                             t-C.sub.4 H.sub.9                                                                 H         (4-OH)C.sub.6 H.sub.10                                            91                                                                             t-C.sub.4 H.sub.9                                                                 CH.sub.3  CH.sub.2 C.sub.6 H.sub.11                                         92                                                                             t-C.sub.4 H.sub.9                                                                 C.sub.2 H.sub.5                                                                          CH.sub.2 C.sub.6 H.sub.11                                         93                                                                             t-C.sub.4 H.sub.9                                                                 (CH.sub.2).sub.2 CH.sub.3                                                                CH.sub.2 C.sub.6 H.sub.11                                         94                                                                             t-C.sub.4 H.sub.9                                                                 CH.sub.3  CH(C.sub.2 H.sub.5).sub.2                                         95                                                                             t-C.sub.4 H.sub.9                                                                 C.sub.2 H.sub.5                                                                          CH(C.sub.2 H.sub.5).sub.2                                         96                                                                             t-C.sub.4 H.sub.9                                                                 (CH.sub.2).sub.2 CH.sub.3                                                                CH(C.sub.2 H.sub.5).sub.2                                         97                                                                             t-C.sub.4 H.sub.9                                                                 H         H                                                                 98                                                                             t-C.sub.4 H.sub.9                                                                 H         CH((CH.sub.2).sub.2 CH(                                                                  (CH.sub.2).sub.4)CHCH.sub.2)                            99                                                                             t-C.sub.4 H.sub.9                                                                 H         CH(n-C.sub.3 H.sub.7).sub.2                                       100                                                                            t-C.sub.4 H.sub.9                                                                 H         (CH.sub.2).sub.2 C.sub.6 H.sub.11                                 101                                                                            t-C.sub.4 H.sub.9                                                                 H         CH(CH.sub.3)(CH.sub.2).sub.4 CH.sub.3                             102                                                                            t-C.sub.4 H.sub.9                                                                 H         CH(C.sub.2 H.sub.5)(CH.sub.2).sub.3 CH.sub.3                      103                                                                            t-C.sub.4 H.sub.9                                                                 CH.sub.2 CHCH.sub.2                                                                      CH.sub.2 CHCH.sub.2                                               104                                                                            t-C.sub.4 H.sub.9                                                                 H         C.sub.7 H.sub.13                                                  105                                                                            t-C.sub.4 H.sub.9                                                                 H         CH(CH.sub.3)(CH.sub.2).sub.5 CH.sub.3                             106                                                                            t-C.sub.4 H.sub.9                                                                 H         C(CH.sub.3).sub.2 CH.sub.2 C(CH.sub.3).sub.3                      107                                                                            t-C.sub.4 H.sub.9                                                                 H         CH(CH.sub.3)(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                   108                                                                            t-C.sub.4 H.sub.9                                                                 H         CH.sub.2 CH.sub.2 (1-cyclohexenyl)                                109                                                                            t-C.sub.4 H.sub.9                                                                 H         ((4-t-butyl)C.sub.6 H.sub.10)                                     110                                                                            t-C.sub.4 H.sub.9                                                                 H         CH(CH.sub.3)CH.sub.2 CH(CH.sub.3).sub.2                           111                                                                            t-C.sub.4 H.sub.9                                                                 H         CH.sub.2 CH.sub.2 -t-C.sub.4 H.sub.9                              112                                                                            t-C.sub.4 H.sub.9                                                                 H         CH(CH.sub.3)CH.sub.2 CH(CH.sub.3)C.sub.2 H.sub.5                  113                                                                               2,4,6-(CH(CH.sub.2).sub.3)                                                               CH.sub.2 CH.sub.2 CH(CH.sub.2).sub.4 CHCH.sub.2                   114                                                                            t-C.sub.4 H.sub.9                                                                 CH.sub.2 CH.sub.2 (1,2-benzylene)CH.sub.2                                   115                                                                               2,4,6-(CH(CH.sub.2).sub.3)                                                               H                                                                 n-C.sub.8 H.sub.17                                                             116                                                                            t-C.sub.4 H.sub.9                                                                           CH.sub.2 CH.sub.2 CH.sub.2 CH(CH.sub.2).sub.4 CH                  117                                                                            t-C.sub.4 H.sub.9                                                                           CH.sub.3  CH.sub.2 CH.sub.2 C.sub.6 H.sub.11                      118                                                                            t-C.sub.4 H.sub.9                                                                 C.sub.2 H.sub.5                                                                          CH.sub.2 CH.sub.2 C.sub.6 H.sub.11                                119                                                                            t-C.sub.4 H.sub.9                                                              n-C.sub.3 H.sub.7                                                                 CH.sub.2 CH.sub.2 C.sub.6 H.sub.11                                          120                                                                            t-C.sub.4 H.sub.9                                                                 H         CH.sub.2 C(CH.sub.2).sub.5 CH.sub.3                               121                                                                            t-C.sub.4 H.sub.9                                                                 CH.sub.3  CH.sub.2 CH(CH.sub.3).sub.2                                       122                                                                            t-C.sub.4 H.sub.9                                                              i-C.sub.3 H.sub.7                                                                 CH.sub.2 CH.sub.2 C.sub.6 H.sub.11                                          123                                                                            t-C.sub.4 H.sub.9                                                              n-C.sub.3 H.sub.7                                                                 CH.sub.2 CH(CH.sub.3).sub.2                                                 124                                                                            t-C.sub.4 H.sub.9                                                                 H         C(CH.sub.3)CHCOCH.sub.2 CH(CH.sub.3).sub.2                        125                                                                            t-C.sub.4 H.sub.9                                                                           CH.sub.3  CH.sub.2(1-methylcyclohexyl)                                                                    --                                     126                                                                            t-C.sub.4 H.sub.9                                                                 C.sub.2 H.sub.5                                                                          CH.sub.2(1-methylcyclohexyl)                                      127                                                                            t-C.sub.4 H.sub.9                                                                 C.sub.3 H.sub.7                                                                          CH.sub.2(1-methylcyclohexyl)                                                             --                                                      128                                                                            t-C.sub.4 H.sub.9                                                                 CH.sub.3                                                                    2-Norbornyl                                                                       --                                                                          129                                                                            t-C.sub.4 H.sub.9                                                                 C.sub.2 H.sub.5                                                             2-Norbornyl                                                                       --                                                                          130                                                                            t-C.sub.4 H.sub.9                                                                 C.sub.3 H.sub.7                                                             2-Norbornyl                                                                       --                                                                          131                                                                            t-C.sub.4 H.sub.9                                                                 CH.sub.3  CH.sub.2 C(CH.sub.3).sub.3                                                               --                                                      132                                                                            t-C.sub.4 H.sub.9                                                                 C.sub.2 H.sub.5                                                                          CH.sub.2 C(CH.sub.3).sub.3                                                               --                                                      133                                                                            t-C.sub.4 H.sub.9                                                                 C.sub.3 H.sub.7                                                                          CH.sub.2 C(CH.sub.3).sub.3                                                               --                                                      134                                                                            t-C.sub.4 H.sub.9                                                                 H         CH.sub.2 C(CH.sub.3).sub.3                                                               --                                                      135                                                                               C(CH.sub.3).sub.2 CH.sub.2                                                               (CH.sub.2).sub.2 CH(CH.sub.3)(CH.sub.2).sub.2                                                             --                                        C(CH.sub.3).sub.3                                                           136                                                                               C(CH.sub.3).sub.2 CH.sub.2                                                               CH.sub.2 CH(CH.sub.3)CH.sub.2 CH(CH.sub.3)CH.sub.2                                                        --                                        C(CH.sub.3).sub.3                                                           137                                                                               C(CH.sub.3).sub.2 CH.sub.2                                                               H         CH.sub.2 CH(CH.sub.3).sub.2                                                                     --                                        C(CH.sub.3).sub.3                                                           138                                                                            t-C.sub.4 H.sub.9                                                                 H                                                                           2-Decalyl                                                                         HCl                                                                         139                                                                               C(CH.sub.3).sub.2 C.sub.6 H.sub.11                                                       H         CH.sub.2 CH(CH.sub.3).sub.2                                                                     --                                     140                                                                               C(CH.sub.3).sub.2 C.sub.6 H.sub.11                                                       CH.sub.3                                                          n-C.sub.6 H.sub.13                                                                --                                                                          141                                                                               C(CH.sub.3).sub.2 C.sub.6 H.sub.11                                                       (CH.sub.2).sub.2 CH(CH.sub.3)(CH.sub.2).sub.2                                                             --                                     142                                                                               C(CH.sub.3).sub.2 C.sub.6 H.sub.11                                                       H         C.sub.6 H.sub.11 --                                     143                                                                            t-C.sub.4 H.sub.9                                                                 CH.sub.2 CH(CH.sub.3).sub.2                                                              CH.sub.2 CH(CH.sub.3).sub.2                                                              --                                                      144                                                                            t-C.sub.4 H.sub.9                                                                 H         (CH.sub.2).sub.2 OCH.sub.3                                                               --                                                      145                                                                            t-C.sub.4 H.sub.9                                                                 H         CH.sub.2(2-THF)                                                                          --                                                      146                                                                            t-C.sub.4 H.sub.9                                                                 H         CH.sub.2 CH(OCH.sub.3).sub.2                                                             --                                                      147                                                                            t-C.sub.4 H.sub.9                                                                 (CH.sub.2).sub.2 OCH.sub.3                                                               (CH.sub.2).sub.2 OCH.sub.3                                                               --                                                      148                                                                            t-C.sub.4 H.sub.9                                                                 CH.sub.3  CH.sub.2 CH(OCH.sub.3).sub.2                                                             --                                                      149                                                                            t-C.sub.4 H.sub.9                                                                 CH.sub.3  CH.sub.2 -2-(1,3-dioxolanyl)                                                             --                                                      150                                                                            t-C.sub.4 H.sub.9                                                                 CH.sub.3  (CH.sub.2).sub.2 OCH.sub.3                                                               --                                                      151                                                                            t-C.sub.4 H.sub.9                                                                 CH.sub.3  CH.sub.2(2-THF)                                                                          --                                                      152                                                                            t-C.sub.4 H.sub.9                                                                 C.sub.2 H.sub.5                                                                          CH.sub.2(2-THF)                                                                          --                                                      153                                                                            t-C.sub.4 H.sub.9                                                                 H         CH.sub.2 CH(OC.sub.2 H.sub.5).sub.2                                                      --                                                      154                                                                            t-C.sub.4 H.sub.9                                                                 C.sub.2 H.sub.5                                                                          CH.sub.2 CH(OCH.sub.3).sub.2                                                             --                                                      155                                                                            t-C.sub.4 H.sub.9                                                                 CH.sub.3  CH.sub.2 CH(OC.sub.2 H.sub.5).sub.2                                                      --                                                      156                                                                            t-C.sub.4 H.sub.9                                                                 C.sub.2 H.sub.5                                                                          CH.sub.2 CH(OC.sub.2 H.sub.5).sub.2                                                      --                                                      157                                                                            t-C.sub.4 H.sub.9                                                                 H         CH.sub.2(1-methylcyclohexyl)                                                             HCl                                                     158                                                                            t-C.sub.4 H.sub.9                                                                 H         CH.sub.2(1-methylcyclohexyl)                                                             HBr                                                     159                                                                            t-C.sub.4 H.sub.9                                                                 H         CH.sub.2(1-methylcyclohexyl)                                                             H.sub.3 BO.sub.3                                        160                                                                            t-C.sub.4 H.sub.9                                                                 H         CH.sub.2(1-methylcyclohexyl)                                                              1/2HOOCCOOH                                            161                                                                            t-C.sub.4 H.sub.9                                                                 H         CH.sub.2(1-methylcyclohexyl)                                                             CH.sub.3 COOH                                           162                                                                            t-C.sub.4 H.sub.9                                                                 H         CH.sub.2(1-methylcyclohexyl)                                                             CF.sub.3 COOH                                           163                                                                            t-C.sub.4 H.sub.9                                                                 H         CH.sub.2(1-methylcyclohexyl)                                                             C.sub.3 H.sub.7 COOH                                    164                                                                            t-C.sub.4 H.sub.9                                                                 H         CH.sub.2(1-methylcyclohexyl)                                                             C.sub.5 H.sub.11 COOH                                   165                                                                            t-C.sub.4 H.sub.9                                                                 H         CH.sub.2(1-methylcyclohexyl)                                                             C.sub.11 H.sub.23 COOH                                  166                                                                            t-C.sub.4 H.sub.9                                                                 H         CH.sub.2(1-methylcyclohexyl)                                                             C.sub.15 H.sub.31 COOH                                  167                                                                            t-C.sub.4 H.sub.9                                                                 H         CH.sub.2(1-methylcyclohexyl)                                                             C.sub.6 H.sub.5 B(OH).sub.2                             168                                                                            t-C.sub.4 H.sub.9                                                                 H         CH.sub.2(1-methylcyclohexyl)                                                             saccharin                                               169                                                                            t-C.sub.4 H.sub.9                                                                 H         CH(C.sub.2 H.sub.5)C.sub.4 H.sub.9                                                       HCl                                                     170                                                                            t-C.sub.4 H.sub.9                                                                 H         CH(C.sub.2 H.sub.5)C.sub.4 H.sub.9                                                       HBr                                                     171                                                                            t-C.sub.4 H.sub.9                                                                 H         CH(C.sub.2 H.sub.5)C.sub.4 H.sub.9                                                       H.sub.3 BO.sub.3                                        172                                                                            t-C.sub.4 H.sub.9                                                                 H         CH(C.sub.2 H.sub.5)C.sub.4 H.sub.9                                                        1/2HOOCCOOH                                            173                                                                            t-C.sub.4 H.sub.9                                                                 H         CH(C.sub.2 H.sub.5)C.sub.4 H.sub.9                                                       CH.sub.3 COOH                                           174                                                                            t-C.sub.4 H.sub.9                                                                 H         CH(C.sub.2 H.sub.5)C.sub.4 H.sub.9                                                       CF.sub.3 COOH                                           175                                                                            t-C.sub.4 H.sub.9                                                                 H         CH(C.sub.2 H.sub.5)C.sub.4 H.sub.9                                                       C.sub.3 H.sub.7 COOH                                    176                                                                            t-C.sub.4 H.sub.9                                                                 H         CH(C.sub.2 H.sub.5)C.sub.4 H.sub.9                                                       C.sub.5 H.sub.11 COOH                                   177                                                                            t-C.sub.4 H.sub.9                                                                 H         CH(C.sub.2 H.sub.5)C.sub.4 H.sub.9                                                       C.sub.11 H.sub.23 COOH                                  178                                                                            t-C.sub.4 H.sub.9                                                                 H         CH(C.sub.2 H.sub.5)C.sub.4 H.sub.9                                                       C.sub.15 H.sub.31 COOH                                  179                                                                            t-C.sub.4 H.sub.9                                                                 H         CH(C.sub.2 H.sub.5)C.sub.4 H.sub.9                                                       C.sub.6 H.sub.5 B(OH).sub.2                             180                                                                            t-C.sub.4 H.sub.9                                                                 H         CH(C.sub.2 H.sub.5)C.sub.4 H.sub.9                                                       saccharin                                               __________________________________________________________________________

                  TABLE Ia.sup.1                                                   ______________________________________                                          ##STR6##                                                                      R.sup.1  R.sup.4       R.sup.5       ACID                                      ______________________________________                                         181                                                                            t-C.sub.4 H.sub.9                                                                           H             H           --                                      182                                                                            t-C.sub.4 H.sub.9                                                                   H       C.sub.6 H.sub.11                                                                             --                                                  183                                                                            t-C.sub.4 H.sub.9                                                                   H                                                                         n-C.sub.8 H.sub.17                                                                  --                                                                        184                                                                            t-C.sub.4 H.sub.9                                                                   H                                                                         n-C.sub.6 H.sub.13                                                                  --                                                                        185                                                                            t-C.sub.4 H.sub.9                                                                   H       C.sub.6 H.sub.11                                                                             HCl                                                 186                                                                            t-C.sub.4 H.sub.9                                                                   CH.sub.2 CH(CH.sub.3).sub.2                                                            CH.sub.2 CH(CH.sub.3).sub.2                                                                  --                                                  187                                                                            t-C.sub.4 H.sub.9                                                                   CH.sub.3                                                                               C.sub.6 H.sub.11                                                                             --                                                  188                                                                            t-C.sub.4 H.sub.9                                                                   C.sub.2 H.sub.5                                                                        C.sub.6 H.sub.11                                                                             --                                                  ______________________________________                                    

                  TABLE Ib.sup.1                                                   ______________________________________                                          ##STR7##                                                                      R.sup.1   R.sup.4   R.sup.5         ACID                                       ______________________________________                                         189                                                                            t-C.sub.4 H.sub.9                                                                            H         C.sub.6 H.sub.11                                                                             --                                       190                                                                            t-C.sub.4 H.sub.9                                                                   H        H         HCl                                                    191                                                                            t-C.sub.4 H.sub.9                                                                   CH.sub.3 CH.sub.3  --                                                     192                                                                            t-C.sub.4 H.sub.9                                                                   H        (3-methyl)-cyclohexyl                                                                    --                                                     193                                                                            t-C.sub.4 H.sub.9                                                                   H        CH(C.sub.3 H.sub.7)C.sub.3 H.sub.7                                                       HCl                                                    194                                                                            t-C.sub.4 H.sub.9                                                                   H        CH(CH.sub.3)C.sub.5 H.sub.11                                                             --                                                     195                                                                            t-C.sub.4 H.sub.9                                                                   H        C.sub.7 H.sub.13                                                                         --                                                     196                                                                            t-C.sub.4 H.sub.9                                                                   C.sub.4 H.sub.9                                                           n-C.sub.4 H.sub.9                                                                   --                                                                        197                                                                            t-C.sub.4 H.sub.9                                                                   H        CH(C.sub.2 H.sub.5)C.sub.4 H.sub.9                                                       --                                                     198                                                                            t-C.sub.4 H.sub.9                                                                   H                                                                         2-decalyl                                                                           --                                                                        199                                                                            t-C.sub.4 H.sub.9                                                                   CH.sub.3 C.sub.6 H.sub.11                                                                         --                                                     200                                                                            t-C.sub.4 H.sub.9                                                                   C.sub.2 H.sub.5                                                                         C.sub.6 H.sub.11                                                                         --                                                     201                                                                            t-C.sub.4 H.sub.9                                                                   CH.sub.3 CH(CH.sub.3)C.sub.5 H.sub.11                                                             --                                                     202                                                                            t-C.sub.4 H.sub.9                                                                   C.sub.2 H.sub.5                                                                         CH(CH.sub.3)C.sub.5 H.sub.11                                                             --                                                     203                                                                            t-C.sub.4 H.sub.9                                                                            (CH.sub.2).sub.5      --                                         204                                                                            t-C.sub.4 H.sub.9                                                                   (CH.sub.2).sub.2 O(CH.sub.2).sub.2                                                      --                                                               205                                                                            t-C.sub.4 H.sub.9                                                                            H         (4-t-butyl)-cyclohexyl                                                                       --                                       206                                                                            t-C.sub.4 H.sub.9                                                                   H        (4-methyl)-cyclohexyl                                                                    --                                                     207                                                                            t-C.sub.4 H.sub.9                                                                   H        (2-methyl)-cyclohexyl                                                                    --                                                     208                                                                            t-C.sub.4 H.sub.9                                                                   H        C.sub.5 H.sub.9                                                                          --                                                     209                                                                            t-C.sub.4 H.sub.9                                                                   H        (CH.sub.2)-2-THF                                                                         --                                                     210                                                                            t-C.sub.4 H.sub.9                                                                   CH.sub.3 CH(C.sub.2 H.sub.5)C.sub.4 H.sub.9                                                       --                                                     211                                                                            t-C.sub.4 H.sub.9                                                                   C.sub.2 H.sub.5                                                                         CH(C.sub.2 H.sub.5)C.sub.4 H.sub.9                                                       --                                                     212                                                                            t-C.sub.4 H.sub.9                                                                   C.sub.3 H.sub.7                                                                         CH(C.sub.2 H.sub.5)C.sub.4 H.sub.9                                                       --                                                     ______________________________________                                          THF means tetrahydrofurfuryl, acid means that the compound is a ammonium       salt of the denoted acid                                                       .sup.1 C.sub.6 H.sub.5 means phenyl, C.sub.7 H.sub.13 means cycloheptyl,       C.sub.6 H.sub.11 means cyclohexyl, C.sub.5 H.sub.9 means cyclopentyl,          C.sub.3 H.sub.5 means cyclopropyl, C.sub.5 H.sub.4 N means pyridyl,            C.sub.6 H.sub.10 means cyclohexylene.                                          .sup.2 All substituents R.sup.1 are at the four position of the cyclohexy      ring except compounds 113 and 115 which are derived from adamantanone.   

Physical data for the above compounds are set out in Tables II, III, IV and V.

                  TABLE II                                                         ______________________________________                                         Melting Point (°C.)                                                     Compound No.                                                                   ______________________________________                                          1                  50-60                                                       4                 115-115                                                      6                  72-75                                                       9                  68-75                                                      10                  82-87                                                      11                  72-77                                                      15                  48-60                                                      19                  50-60                                                      21                  60-63                                                      22                 135                                                         23                 122-125                                                     24                 140                                                         25                 115                                                         26                  48-52                                                      28                  40-42                                                      29                  50-52                                                      37                 250 (dec.)                                                  38                 190-200                                                     40                 105-115                                                     50                  85-90 (HCl salt)                                           51                 270-275 (HCl salt)                                          52                  44-47                                                      53                  61-65                                                      56                  47-57                                                      56                 226-234 (HCl salt)                                          57                 261-273 (HCl salt)                                          58                 253-262 (HCl salt)                                          97                  80-92                                                      109                 76-80                                                      111                 56-60                                                      114                 75-76                                                      128                 60-65                                                      138                249-53                                                      141                 91-97                                                      143                 42-44                                                      157                248-55 Dec.                                                 158                254-56 Dec.                                                 160                210-212                                                     162                195-96 Dec.                                                 168                216-20 Dec.                                                 172                156-58                                                      185                243-46 Dec.                                                 190                260-65                                                      ______________________________________                                    

                  TABLE III                                                        ______________________________________                                         Refraction Index (n.sub.D .sup.22)                                             Compound No.                                                                   ______________________________________                                          2                 1.4750                                                       5                 1.4765                                                       7                 1.4748                                                       8                 1.4752                                                      12                 1.4749                                                      13                 1.4748                                                      14                 1.4744                                                      16                 1.4928                                                      17                 1.4938                                                      18                 1.4889                                                      20                 1.4942                                                      27                 1.4752                                                      30                 1.5105                                                      31                 1.5191                                                      32                 1.4740                                                      33                 1.5326                                                      34                 1.5389                                                      35                 1.4971                                                      36                 1.4883                                                      39                 1.5140                                                      42                 1.4748                                                      43                 1.4750                                                      44                 1.4745                                                      45                 1.4742                                                      46                 1.4748                                                      47                 1.5202                                                      48                 1.5086                                                      49                 1.4877                                                      54                 1.5201                                                      55                 1.5120                                                      59                 1.4734                                                      60                 1.4769                                                      61                 1.5148                                                      62                 1.4759                                                      64                 1.4758                                                      65                 1.4760                                                      66                 1.4739                                                      67                 1.4770                                                      68                 1.4780                                                      69                 1.4732                                                      70                 1.4872                                                      71                 1.4870                                                      72                 1.4757                                                      72                 1.4731                                                      74                 1.4729                                                      75                 1.4680                                                      76                 1.4736                                                      77                 1.4865                                                      78                 1.4755                                                      79                 1.4966                                                      80                 1.4945                                                      81                 1.4735                                                      82                 1.4922                                                      83                 1.4763                                                      84                 1.4735                                                      85                 1.5034                                                      87                 1.4894                                                      89                 1.4898                                                      91                 1.4909                                                      92                 1.4900                                                      93                 1.4899                                                      94                 1.4739                                                      95                 1.4740                                                      96                 1.4748                                                      97                 1.4840                                                      99                 1.4726                                                      101                1.4737                                                      102                1.4735                                                      103                1.4879                                                      104                1.4955                                                      105                1.4733                                                      106                1.4761                                                      107                1.4724                                                      108                1.4994                                                      110                1.4766                                                      113                1.5248  (24° C.)                                     115                1.5023  (24° C.)                                     116                1.5072                                                      117                1.4898                                                      118                1.4910                                                      119                1.4868                                                      120                1.4902                                                      121                1.4731                                                      122                1.4890                                                      123                1.4720                                                      125                1.4921                                                      126                1.4939                                                      127                1.4906                                                      129                1.4996                                                      131                1.4750                                                      132                1.4754                                                      133                1.4734                                                      136                1.4874  (24° C.)                                     137                1.4797  (24° C.)                                     139                1.4958  (25° C.)                                     140                1.4929  (25° C.)                                     142                1.5002  (25° C.)                                     144                1.4759                                                      145                1.4881                                                      146                1.4745                                                      147                1.4769                                                      148                1.4733                                                      149                1.4850                                                      150                1.4752                                                      151                1.4856                                                      152                1.4888                                                      153                1.4673                                                      154                1.4739                                                      155                1.4665                                                      156                1.4699                                                      181                1.4817                                                      183                1.4840                                                      184                1.4843                                                      186                1.4707                                                      187                1.4900                                                      188                1.4915                                                      191                1.4714                                                      192                1.4862                                                      193                1.4721                                                      196                1.4700                                                      197                1.4722                                                      198                1.5023                                                      199                1.4891                                                      200                1.4913                                                      201                1.4717                                                      202                1.4720                                                      ______________________________________                                    

                  TABLE IV                                                         ______________________________________                                         Elemental Analysis                                                                     C         H          N                                                 Compound No.                                                                             Calc.   Found   Calc.                                                                               Found Calc. Found                               ______________________________________                                          41       70.93   69.26   11.62                                                                               11.93 3.93  4.80                                 63       75.80   75.24   12.33                                                                               11.91 5.52  6.60                                100       78.44   75.66   12.22                                                                               12.10 4.35  4.63                                112       77.60   74.41   12.70                                                                               11.90 4.52  5.29                                ______________________________________                                    

                  TABLE V                                                          ______________________________________                                         Molecular weight                                                               (determined by mass spectrometry)                                              Compound No.      Calc.  Found                                                 ______________________________________                                          3                309    309                                                    86               345    345                                                    88               307    307                                                   124               335    335                                                   203               307    307                                                   204               321    321                                                   205               378    378                                                   206               335    335                                                   207               335    335                                                   208               307    307                                                   209               323    323                                                   210               351    351                                                   211               365    365                                                   212               379    379                                                   ______________________________________                                    

EXAMPLE 182 (compound 182)

8-t-Butyl-3-cyclohexylaminomethyl-1-oxaspiro(4,5)decane

(i) Preparation of 8-t-butyl-3-hydroxy-1-oxaspiro(4,5)decane

To an ice cooled solution of 8-t-butyl-1-oxaspiro(4,5)decane-3-one (44.1 g, 0.21 mmol) in methanol (300 ml) was added sodium borohydride (10.8 g, 0.285 mol) in portions. After the evolution of hydrogen ceased the cooling bath was removed and the mixture was stirred at room temperature over night. The solvent was evaporated in vacuo and the residue was taken up in toluene/diluted hydrochloric acid. The organic layer was washed twice with water (200 ml), dried (MgSO₄) and evaporated in vacuo to yield a colourless oil (44 g) which was recrystallised from light petroleum. 30 g of colourless crystals were obtained which melted at 82°-84° C. TLC and NMR-analysis indicated a single diastereoisomer only (cis).

(ii) Preparation of 8-t-butyl-3-(p-toluenesulfonyloxy)-1-oxaspiro-(4,5)decane

To a solution of 8-t-butyl-3-hydroxy-1-oxaspiro(4,5)decane (4.24 g, 20 mmol) in THF (50 ml) was added sodium hydride (0.72 g, 24 mmol, 80% in mineral oil) and the mixture was heated to reflux for 3 hours. p-Toluenesulfonylchloride (4.56 g, 24 mmol) in THF (10 ml) was then added and heating was continued for another 3 hours. The solvent was evaporated, toluene and water were added (50 ml, each) and the phases were separated. A pale yellow oil (7.3 g) was isolated from the organic layer which was treated with light petroleum to yield colourless crystals (5.6 g), melting at 101° C.

(iii) Preparation of 8-t-butyl-3-cyano-1-oxaspiro(4,5)decane

A mixture of 8-t-butyl-3-(p-toluenesulfonyloxy)-1-oxaspiro-(4,5)decane (18.3 g, 50 mmol) and sodium cyanide (4.9 g, 100 mmol) in dry DMF (75 ml) was heated to 100° C. for 6 hours. Light petroleum/ethylacetate 4:1 (50 ml) was added and the mixture was filtrated from insoluble material. The filtrate was then evaporated in vacuo and the resulting residue was taken up in toluene (100 ml). It was washed with water, dried (MgSO₄) and evaporated in vacuo to yield a brownish oil (11.0 g) which was Kugelrohr distilled (120°-125° C., 0.015 mbar) to furnish the product as colourless crystals (8.94 g, m.p. 35°-40° C.).

Compound 181

(iv) Preparation of 8-t-butyl-3-aminomethyl-1-oxaspiro(4,5)decane

To a solution of lithium aluminum hydride (LAH) (2.19 g, 58 mmol) in THF (100 ml) was added 8-t-butyl-3-cyano-1-oxaspiro-(4,5)decane (8.5 g, 38.5 mmol) in THF (25 ml). The reaction mixture was refluxed for 3 hours. After cooling excess LAH was carefully destroyed by addition of saturated, aqueous sodium sulfate solution. The reaction mixture was filtrated from insoluble material and the filtrate was evaporated in vacuo. The pale yellow oil (8.6 g) was purified by Kugelrohr distillation (125°-135° C., 0.05 mbar) to yield the product as a colourless liquid (5.7 g n_(D) ²² : 1.4817).

(v) Preparation of 8-t-butyl-3-cyclohexylaminomethyl-1-oxaspiro-(4,5)decane

To a solution of 8-t-butyl-3-aminomethyl-1-oxaspiro(4,5)-decane (1.2 g, 5.3 mmol), cyclohexanone (0.54 g, 5.5 mmol) and zinc chloride (0.4 g, 3 mmol) in methanol (15 ml) was added sodium cyanoborohydride (0.4 g, 6.4 mmol). The reaction mixture was stirred over night. The solvent was then evaporated in vacuo and the resulting residue was treated with a mixture of saturated aqueous sodium carbonate/toluene (50 ml each). The organic layer was separated, dried (MgSO₄) and evaporated in vacuo to yield 1.7 g of a pale yellow oil which was purified by flash chromatography (toluene/ethanol 4:1). Evaporation of the fractions containing the product yielded a colourless oil (1.5 g).

1H-NMR(CDCl₃ /ppm): 3.93(dd, 1H); 3.45(dd, 1H); 2.59(t,2H); 2.37(m, 1H); 1.88-087(m,22H); 0.82 (s,9H).

EXAMPLES 183-188

By processes similar to those described in Example 182, compounds 127 (8-t-butyl-3-n-octylaminomethyl-1-oxaspiro(4,5)-decane; n_(D) ²² 1.4840) and 128 (8-t-butyl-3-n-hexylaminomethyl-1-oxaspiro(4,5)decane; n_(D) ²² 1.4843) were prepared.

EXAMPLE 181

8-t-Butyl-3-aminomethyl-1-oxaspiro(4,5)decane

This compound is prepared according to the steps (i) to (iv) of Example 182.

EXAMPLE 189 (compound 190)

8-t-Butyl-3-cyclohexylaminoethyl-1-oxaspiro(4,5)decane

(i) Preparation of 8-t-butyl-3-aminoethyl-1-oxaspiro(4,5)decane hydrochloride

To a mixture of cyanoacetic acid (10.2 g, 0.12 mol) and pyridine (50 ml) was added piperidine (0.85g, 0.01 mol) and 8-t-butyl-1-oxaspiro(4,5)decane-3-one. The mixture was heated to reflux until the evolution of carbon dioxide ceased (4 hours). The solvent was then evaporated in vacuo and toluene (50 ml) was added and distilled off two times. The resulting yellow oil (24 g) was filtrated over a plug of silica (toluene/5% ethylacetate) to remove polar side products. Evaporation of the organic washings resulted in a pale yellow oil (19.4 g) which was transferred to the hydrogenation step without further purification.

The above product was dissolved in methanol (200 ml). Concentrated hydrochloric acid (8.2 ml) and platinum oxide was added and the mixture was hydrogenated (60° C., 5 bar) until hydrogen uptake ceased. The solvent was then evaporated in vacuo and toluene (100 ml) was added/distilled off the residue two times. The resulting residue was then treated with light petroleum (150 ml). Colourless crystals (8.7 g) were isolated by filtration (m.p. 260°-65° C.).

(ii) Preparation of 8-t-butyl-3-cyclohexylaminoethyl-1-oxaspiro-(4,5)decane)

To a solution of 8-t-butyl-3-aminoethyl-1-oxaspiro(4,5)decane hydrochloride (1.10 g, 4 mmol) in methanol (15 ml) was added sodium methylate (4 ml, 1N in methanol), cyclohexanone (0.41 g, 4.2 mmol) zinc chloride (0.32 g, 2.5 mmol) and sodium cyanoborohydride (0.32 g, 5 mmol). The reaction mixture was stirred at room temperature over night. The solvent was removed in vacuo and the residue was taken up in toluene (50 ml)/sat. aqueous sodium carbonate (50 ml). Drying and evaporation of the organic layer furnished the product as a colurless oil (1.3 g). It was purified by flash chromatography (light petroleum/triethylamine 10:1). Evaporation of the fractions containing the product furnished a colourless oil (1.0 g). 1H-NMR (CDCl₃, ppm): 3.93 (t,1H); 3.37(t,1H); 2.58(m,2H); 2.37(m, 1H); 2.27(m, 1H); 1.93-0.90(m,24H); 0.85(s,9H).

EXAMPLE 213

8-t-Butyl-3-cyclohexylaminomethyl-3-hydroxy-1-oxaspiro-(4,5)decane

(i) Preparation of 8-t-butyl-3-hydroxy-3-cyano-1-oxaspiro-4,5)decane

To a solution of 8-t-butyl-1-oxaspiro(4,5)decane-3-one (2.1 g, 10 mmol) in ethanol (20 ml) was added finely powdered sodium cyanide (0.73 g, 15 mmol) with stirring. Acetic acid (1.2 g, 20 mmol) was then added and the reaction mixture was stirred at room temperature overnight. The solvent was then evaporated in vacuo, toluene (50 ml) was added to the residue and the mixture was filtrated. Evaporation of the filtrate in vacuo resulted in a residue which was recrystallized from light petroleum to yield a colourless powder (1.25 g, m.p. 114°-116° C.). TLC and NMR analysis indicated the compound being a single diastereoisomer (cis).

(ii) Preparation of 8-t-butyl-3-aminomethyl-3-hydroxy-1-oxaspiro(4,5)decane

8-t-Butyl-3-hydroxy-3-cyano-1-oxaspiro(4,5)decane (2.37 g, 10 mmol) in methanol (25 ml), containing conc. hydrochloric acid (1 ml), was hydrogenated on platinum oxide (0.1 g, 40° C./5 bar hydrogen pressure) until the uptake of hydrogen ceased. Saturated NaHCO₃ (3 ml) was added and the solvent was evaporated in vacuo. To the residue was added methanol (30 ml) and MgSO₄. The mixture was filtrated and the filtrate was evaporated in vacuo to yield a pale greenish solid (2.0 g). The fairly polar compound was not further purified. It was characterised via its N-cyclohexyl derivative.

(iii) Preparation of 8-t-butyl-3-cyclohexylaminomethyl-3-hydroxyl-1-oxaspiro(4,5)decane

To a solution of 8-t-butyl-3-aminomethyl-3-hydroxy-1-oxaspiro-(4,5)decane (1.8 g, 7.5 mmol), cyclohexanone (1.36 g, 8 mmol) and zinc chloride (0.61 g, 4.5 mmol) in methanol (20 ml) was added sodium cyanoborohydride (0.56 g, 9 mmol). The reaction mixture was stirred at room temperature overnight. The solvent was then evaporated in vacuo and to the resulting residue was added saturated sodium carbonate solution and toluene (50 ml each). The organic layer was separated, dried (MgSO₄) and evaporated in vacuo to yield a semisolid residue (2.0 g) which was treated with light petroleum. A colourless powder was isolated by filtration (1.0 g) which melted at 113°-115° C.

EXAMPLE 214 (compound 99)

3-Hept-4-ylamino-8-t-butyl-1-oxaspiro(4,5)-decane (compound 99)

(i) Preparation of 8-t-butyl-1-oxaspiro(4,5)decane-3-one oxime

To a solution of hydroxylamine hydrochloride (6.9 g, 0.1 mol) and triethylamine (10.0 g, 0.1 mol) in 10 ml of water was added 8-t-butyl-1-oxaspiro(4,5)decane-3-one (16.0 g, 0.076 mol) in 30 ml tetrahydrofuran. The mixture was stirred at room temperature for 3 hours and at 60° C. for 1 hour. The solvent was then evaporated in vacuo and the residue was partitioned between toluene and brine (100 ml each). The organic layer was washed with brine, dried (MgSO₄) and evaporated in vacuo to yield a colourless oil (17.0 g) which crystallised on standing. Recrystallisation from light petroleum gave two fractions of colourless crystals (6.6 g and 5.3 g) mp.: 118°-120 and 105-108° C. ¹ H-NMR indicated mixtures of geometric isomers (E/Z) in ratios of 1:1 and 2:1 respectively.

(ii) Preparation of 3-amino-8-t-butyl-1-oxaspiro(4,5)-decane

8-t-Butyl-1-oxaspiro(4,5)-decane-3-one oxime (17.5 g, 76 mmol) in tetrahydrofuran (50 ml) was added to a solution of lithium- aluminium hydride (4.5 g, 0.125 mol) in tetrahydrofuran (100 ml). The reaction mixture was refluxed for 4 hours, cooled end excess LAH was hydrolysed by addition of saturated aqueous sodium sulfate. solids were filtered off washed with tetrahydrofuran and the solvent was stripped off in vacuo. Kugelrohr distillation of the resulting pale yellow oil (16.9 g) gave a colourless oil (12.3 g) Bp.: 125° C./0.02 mbar, n_(D) ²² :1.4840.

(iii) Preparation of 3-hept-4-ylamino-8-t-butyl-1-oxaspiro(4,5)-decane)

To 3-amino-8-t-butyl-1-oxaspiro(4,5)-decane (1.12 g, 5 mmol) and heptane-4-one (0.6 g, 5.25 mmol) in dry methanol (20 ml) was added zinc chloride (0.41 g, 3 mmol). The mixture was stirred at room temperature for 5 minutes and sodium cyanoborohydride 0.38 g, 6 mmol) was added and the resulting heterogeneous mixture was stirred at room temperature overnight. The solvent was then stripped off in vacuo, toluene (50 ml) and 2N NaOH (50 ml) was added. The aqueous phase was extracted twice with toluene (2×50 ml) and the combined organic layers were dried (MgSO₄) and concentrated in vacuo. The resulting oil was purified by flash chromatography to give a pale yellow oil (1.12 g). n_(D) ²² :1.4726.

Fungicidal activity

The fungicidal activity of compounds of the invention was investigated by means of the following tests.

(a) Antisporulant activity against vine downy mildew (Plasmopara viticola; PVA)

The test is a direct antisporulant one using a foliar spray. The lower surfaces of leaves of whole vine plants (cv Cabernet Sauvignon), approximately 8 cm high, are inoculated by spraying with an aqueous suspension containing 5×10⁴ zoosporangia/ml. The inoculated plants are kept for 24 hours at 21° C. in a high humidity compartment, then 24 hours at glasshouse ambient temperature and humidity. Infected leaves are sprayed on their lower surfaces with a solution of active material in 1:1 water/acetone containing 0.04% "TWEEN 20" (Trade Mark; a polyoxyethylene sorbitan ester surfactant). Plants are treated using an automated sprayline with an atomising nozzle. The concentration of the compound is 600 ppm, and the spray volume is 750 l/ha. After spraying, the plants are returned to normal glasshouse conditions for 96 hours and are then transferred to the high humidity compartment for 24 hours to induce sporulation. Assessment is based on the percentage of the leaf area covered by sporulation compared with that on control leaves.

b) Activity against tomato early blight (Alternaria solani; AS)

This test measures the contact prophylactic activity of test compounds applied as a foliar spray. Tomato seedlings (cv Outdoor Girl) are grown to the stage at which the second true leaf is expanded. The plants are treated using an automated sprayline as described under (a). Test compounds are applied as solutions or suspensions in a mixture of acetone and water (50:50 v/v) containing 0.04% surfactant ("TWEEN 20"--Trade Mark). After drying the plants are kept for 24 hours in a glasshouse at 20° C. and 40% R.H., followed by inoculation of the leaf upper surfaces with a suspension of A. solani conidia containing 10⁴ spores/ml. For 4 days after inoculation plants are kept moist in a humidity compartment at 21° C. Disease is assessed 4 days after inoculation, based on the percentage of leaf surface area covered by lesions when compared with control plants.

(c) Direct protectant activity against broad bean grey mould (Botrytis cinerea; BCB)

The test is a direct protectant foliar spray. The upper surfaces of leaves of broad bean plants with two leaf pairs (cv The Sutton) are sprayed with the test compound at a dosage of 600 ppm using an automated sprayline as described under (a). 24 hours after spraying the leaves are inoculated with an aqueous suspension containing 10⁶ conidia/ml. For 4 days after inoculation plants are kept in a high humidity compartment at 22° C. Disease is assessed 4 days after inoculation, based on the percentage of leaf surface area covered by lesions.

(d) Activity against wheat leafspot (Leptosphaeria nodorum; LN.)

The test is a direct therapeutic foliar spray. Leaves of wheat plants (cv Norman), at the single leaf stage, are inoculated by spraying with an aqueous suspension containing 1.5×10⁶ conidia/ml. The inoculated plants are kept for 24 hours in a high humidity compartment prior to treatment. The plants are sprayed with a solution of the test compound at a dosage of 600 ppm using an automated sprayline as described under (a). After drying, the plants are kept for 6-8 days at 22° C. and moderate humidity (70%). Assessment is based on the density of lesions per leaf compared with that on leaves of control plants.

(e) Activity against barley powdery mildew (Erysiphe graminis f.sp. hordei; EGT)

The test is a direct therapeutic foliar spray. Leaves of barley seedlings, (cv. Golden Promise) at the single leaf stage are inoculated by dusting with mildew conidia one day prior to treatment with the test compound. The inoculated plants are kept overnight at glasshouse ambient temperature (18° C.) and humidity (40%) prior to treatment. The plants are sprayed with the test compound at a dosage of 600 ppm using an automated sprayline as described under (a). After drying, plants are returned to a compartment at 18° C. and 40% humidity for up to 7 days. Assessment is based on the percentage of leaf area covered by sporulation compared with that on leaves of control plants.

(f) Direct protectant activity against barley powdery mildew (Erysiphe graminis f.sp. hordei; EGP)

The test is a direct protectant foliar spray. Leaves of barley seedlings (cv Golden Promise) at the single leaf stage are sprayed with the test compound as described under (a). After drying, the plants are kept for 24 hours in a glasshouse at 18° C. and 40% R.H. Then the plants are inoculated by dusting with mildew conidia and kept at 18° C. and 40% R.H. for 8 days. Assessment is based on the percentage of leaf area covered by sporulation compared with that on leaves of control plants.

(g) Direct protectant activity against tomato late blight Phytophthora infestants: PIP)

The test is a direct protectant foliar spray. Tomato plants with two expanded leaves (cv First in the Field) are sprayed with the test compound as described Under (a). After drying, the plants are kept for 24 hours in the glasshouse at 20° C. and 40% R.H. Then, the upper surfaces of the leaves are inoculated with an aqueous suspension containing 2×10⁵ zoosporangia/ml. The inoculated plants are kept for 24 hours at 18° C. in a high humidity cabinet and 5 days at 15° C. and 80% R.H. in a growth chamber with 14 hours light/day. The assessment is based on the percentage of diseased leaf area compared with that on control leaves.

(h) Activity against wheat eyespot in-vitro (Pseudocercosporella herpotrichoides; pHI)

This test measures the in vitro activity of compounds against the fungus causing wheat eyespot. The test compound is dissolved or suspended in acetone and is added into 4 ml aliquots of half strength Potato Dextrose Broth (PDB) dispended in 25-compartment petri dishes to give a final concentration of 10ppm. The fungal inoculum consists of mycelial fragments of P. herpotrichoides grown in half strength PDB in shaken flasks and added to the broth to provide 5×10⁴ fragments/ml broth. Petri dishes are incubated at 20° C. for 10 days until the assessment of mycelial growth.

(i) Activity against Rhizoctonia in-vitro (Rhizoctonia solani: RSI)

This test measures the in-vitro activity of compounds against R. solani that causes stem and root rots. The test compound in acetone is added into 4 ml aliquots of half strength Potato Dextrose Broth dispensed in 25-compartment petri dishes to give final concentrations of 10 ppm. The fungal inoculum consists of mycelial fragments of R. solani growth in half strength PDB in shaken culture flasks and added to the broth to provide 5×10⁴ fragments/ml broth. Petri dishes are incubated at 20° C. for 10 days until the assessment of mycelial growth.

(j) Activity against apple scab in-vitro (Venturia inaequalis: VII)

This test measures the in-vitro activity of compounds against V. inaequalis that causes apple scab. The test compound in acetone is added into 4 ml aliquots of half strength Potato Dextrose Broth dispensed in 25-compartment petri dishes to give final concentrations of 10 ppm. The fungal inoculum consists of mycelial fragments and spores of V. inaequalis grown on malt agar and added to the broth to provide 5×10⁴ propagules/ml broth. Petri dishes are incubated at 20° C. for 10 days until the assessment of mycelial growth.

(k) Activity against rice leaf blast (Pyricularia oryzae; PO)

The test is a direct therapeutic foliar spray. The leaves of rice seedlings (cv Aichiaishi--about 30 seedlings per pot) at the stage of the second leaf beginning to bend are sprayed with an aqueous suspension containing 105 spores/ml 24 hours prior to treatment with the test compound. The inoculated plants are kept overnight in high humidity and then allowed to dry before spraying with the test compound at a dosage of 600 ppm using an automated sprayline as described under (a). After treatment the plants are kept in a rice compartment at 25°-30° C. and high humidity. Assessments are made 4-5 days after treatment and are based on the density of necrotic lesions per leaf when compared with control plants.

The extent of disease control in all the above tests is expressed as a rating compared with either an untreated control or a diluent-sprayed-control, according to the criteria:

0=less than 50% disease control

1=about 50-80% disease control

2=greater than 80% disease control

The results of the tests are set out in Table VI below.

                                      TABLE VI                                     __________________________________________________________________________     Comp                                                                               PVA                                                                               AS BCB                                                                               LN EGT                                                                               EGP                                                                               PIP                                                                               PHI                                                                               RSI                                                                               VII                                                                               PO                                           __________________________________________________________________________      1  0  0  0  0  2  -  0  1  0  0  0                                             2  0  0  0  0  2  -  0  1  1  0  0                                             3  0  0  0  0  1  -  0  2  0  2  0                                             4  0  0  0  1  2  2  0  1  0  1  0                                             5  0  0  1  0  2  2  0  0  1  0  0                                             6  0  0  1  0  2  2  0  0  1  1  0                                             7  0  0  1  0  2  2  0  2  2  2  0                                             8  0  0  1  0  2  2  0  1  0  1  0                                             9  0  0  0  1  2  2  0  1  0  1  0                                            10  0  0  2  1  2  2  0  1  0  1  0                                            11  0  0  0  0  0  2  0  1  0  1  0                                            12  0  0  2  0  2  2  0  0  0  2  0                                            13  0  0  0  0  2  2  0  0  0  2  0                                            14  0  0  0  1  2  2  0  2  1  2  0                                            15  0  0  0  0  2  2  0  0  0  2  0                                            16  0  2  1  1  2  2  0  0  0  2  0                                            17  0  0  0  0  2  2  0  0  0  0  0                                            18  0  0  0  1  2  2  0  0  0  1  0                                            19  0  0  0  1  2  2  0  0  0  1  0                                            20  0  0  0  0  2  2  0  0  0  1  0                                            21  0  0  2  0  2  2  0  0  0  1  0                                            22  0  0  0  0  1  1  0  0  0  0  0                                            23  0  0  0  0  0  0  0  0  0  2  0                                            24  0  0  0  0  0  0  0  0  0  0  0                                            25  0  0  0  0  0  0  0  0  0  0  0                                            26  0  1  0  0  2  2  0  1  0  1  0                                            27  0  0  0  0  2  2  0  1  0  1  0                                            28  0  0  0  0  2  2  0  0  0  2  0                                            29  0  0  0  0  2  2  0  0  0  2  0                                            30  0  0  0  0  2  2  0  0  0  2  0                                            31  2  1  0  0  2  2  0  0  0  1  0                                            32  0  0  0  0  2  2  0  0  0  0  0                                            33  0  0  0  0  1  0  0  0  0  0  0                                            34  0  0  0  0  2  2  0  0  0  0  0                                            35  0  0  0  0  0  0  0  0  0  0  0                                            36  0  0  0  0  2  2  0  0  0  1  0                                            37  0  0  1  0  2  2  0  1  0  0  0                                            38  0  2  0  0  2  2  0  2  1  0  0                                            39  0  2  0  0  2  2  0  1  0  0  0                                            40  0  2  0  0  2  2  0  1  0  0  0                                            41  0  0  0  1  2  2  0  1  0  0  0                                            42  0  0  0  0  2  2  0  1  0  2  0                                            43  0  0  0  2  2  2  0  0  0  2  0                                            44  0  0  0  0  2  2  0  0  0  0  0                                            45  0  0  0  0  2  2  0  0  0  0  0                                            46  0  0  0  0  2  2  0  0  0  0  0                                            47  0  2  0  0  2  2  0  0  0  1  0                                            48  0  2  0  0  2  2  0  0  0  1  0                                            49  0  0  0  2  2  2  2  2  1  1  0                                            50  0  0  0  0  2  2  0  0  0  1  0                                            51  0  2  0  0  2  2  2  1  1  1  0                                            52  0  0  0  0  2  2  0  1  1  1  0                                            53  0  0  1  0  2  2  0  1  0  1  0                                            54  0  0  0  0  2  2  0  0  0  1  0                                            55  0  0  2  1  2  2  0  0  0  1  0                                            56  0  0  2  2  2  2  0  0  0  1  0                                            57  0  0  0  1  2  2  0  0  0  1  0                                            58  0  0  0  2  2  2  0  0  0  1  0                                            59  0  0  0  0  2  2  0  0  0  0  0                                            60  0  0  0  1  2  2  0  0  2  1  0                                            61  0  0  0  1  2  2  0  2  0  1  0                                            62  0  0  1  0  2  2  0  0  0  0  0                                            63  0  0  0  0  2  2  0  0  0  0  0                                            64  0  0  2  0  2  2  2  0  0  0  0                                            65  0  0  2  0  2  2  0  0  0  0  0                                            66  0  0  2  0  2  2  0  0  0  0  0                                            67  0  0  0  1  2  2  2  0  0  0  1                                            68  0  0  0  0  2  2  0  0  0  1  1                                            69  0  0  0  0  2  2  0  0  0  2  1                                            70  0  1  0  0  2  2  2  0  0  1  0                                            71  0  0  0  1  2  2  2  0  0  1  0                                            72  0  0  0  0  2  2  0  0  0  1  0                                            73  0  0  1  0  2  2  0  0  0  0  0                                            74  0  0  0  0  2  2  0  0  0  0  0                                            75  0  0  2  0  2  2  0  0  0  0  0                                            76  0  0  0  0  2  2  0  0  0  0  0                                            77  0  0  0  0  2  2  0  0  0  0  0                                            78  0  0  1  0  2  2  0  0  0  0  0                                            79  0  0  1  0  2  2  2  0  0  0  0                                            80  0  0  1  1  2  2  2  0  1  0  1                                            81  0  0  2  0  2  2  2  0  0  0  0                                            82  0  0  2  1  2  2  0  0  0  0  0                                            83  0  0  1  0  2  2  0  0  0  0  0                                            84  0  0  0  0  2  2  2  0  1  1  0                                            85  0  0  2  0  2  2  2  0  0  1  0                                            86  0  2  0  0  2  2  2  0  0  1  0                                            87  0  0  0  0  2  2  2  0  1  1  0                                            88  0  0  2  0  2  2  2  0  1  1  0                                            89  1  0  0  1  2  2  0  0  1  0  0                                            90  0  0  2  0  2  2  2  0  0  0  0                                            91  0  0  1  1  2  2  2  2  0  0  0                                            92  0  0  2  0  2  2  2  0  1  0  0                                            93  0  0  0  0  2  2  2  0  1  0  0                                            94  0  0  0  1  2  2  0  0  1  0  0                                            95  0  0  0  0  2  2  0  0  1  0  0                                            96  0  0  0  0  2  2  0  0  1  1  0                                            97  0  0  0  0  2  2  2  0  0  0  0                                            98  0  0  2  0  2  2  2  0  1  2  0                                            99  0  0  0  0  2  2  2  0  0  2  0                                            100 0  0  2  0  2  2  2  1  1  2  0                                            101 0  0  2  0  2  2  0  1  0  2  0                                            102 0  0  1  0  2  2  0  0  0  2  0                                            103 0  0  2  0  2  2  2  0  0  1  0                                            104 0  0  0  1  2  2  2  0  0  1  0                                            105 0  0  1  1  2  2  0  2  2  2  0                                            106 0  0  0  0  2  2  2  0  0  1  0                                            107 0  0  0  0  2  2  2  1  1  1  0                                            108 0  0  2  0  2  2  2  1  1  1  0                                            109 0  1  2  0  2  2  2  1  1  2  0                                            110 0  0  1  0  2  2  2  1  1  1  0                                            111 0  0  1  0  2  2  2  0  1  1  0                                            112 0  0  0  0  2  2  2  1  1  1  0                                            113 0  0  1  0  0  1  1  0  0  1  0                                            114 0  1  2  0  2  2  2  0  0  1  0                                            115 0  0  0  0  2  2  1  1  0  2  0                                            116 0  0  1  0  2  2  0  0  0  2  0                                            117 0  2  0  0  2  2  0  1  1  1  0                                            118 2  0  0  0  2  2  0  1  1  1  0                                            119 0  0  0  0  2  2  0  1  0  1  0                                            120 0  0  1  0  2  2  0  0  1  1  0                                            121 0  0  0  0  2  2  0  0  0  0  0                                            122 0  0  0  0  2  2  0  0  0  0  2                                            123 0  0  0  0  2  2  0  0  0  0  1                                            124 0  0  0  0  2  2  2  0  0  0  0                                            125 0  0  0  0  2  2  0  1  0  1  0                                            126 0  0  0  0  2  2  0  0  0  1  0                                            127 0  0  0  0  2  2  0  0  0  1  0                                            128 0  2  0  0  2  2  0  0  0  1  0                                            129 0  0  0  0  2  2  0  0  0  1  0                                            130 0  0  0  0  2  2  2  0  0  1  0                                            131 0  0  0  0  2  2  0  0  0  1  0                                            132 0  0  0  0  2  2  0  0  0  1  0                                            133 0  0  0  0  2  2  0  0  0  1  0                                            134 0  0  0  0  2  2  0  0  0  0  0                                            135 0  0  0  1  2  2  -- 2  2  1  0                                            136 0  0  0  0  2  2  -- 2  2  0  0                                            137 0  0  0  2  2  2  0  2  2  1  0                                            138 0  0  0  0  0  0  2  0  0  0  0                                            139 0  0  0  1  2  2  0  2  0  2  0                                            140 0  0  0  1  2  2  0  2  2  2  0                                            141 0  0  0  1  2  2  0  2  2  2  0                                            142 0  0  0  0  2  2  1  2  2  2  0                                            143 0  0  0  0  2  2  0  0  0  0  0                                            181 0  0  0  0  2  2  2  0  0  0  0                                            182 0  0  1  1  2  2  0  1  2  2  0                                            183 0  0  0  0  2  2  1  1  2  2  0                                            184 0  0  2  0  2  2  0  1  2  2  0                                            185 0  1  1  0  2  2  0  0  0  0  0                                            186 0  0  0  0  0  2  0  0  0  0  0                                            189 0  0  0  0  2  2  1  0  0  1  0                                            190 1  0  0  0  0  1  2  0  0  0  0                                            191 0  0  0  0  0  2  0  0  0  0  0                                            213 0  2  2  0  2  2  2  0  0  0  1                                            __________________________________________________________________________

Evaluation of In Vivo Fungicidal Activity of Test Compounds

Test compounds are dissolved in acetone and diluted with deionized water containing about 0.05% TWEEN 20®, a polyoxyethylene sorbitan monolaurate surfactant manufactured by Atlas Chemical Industries, to give a concentration of 400 ppm. Subsequent dilutions are made with an 0.05% aqueous solution of TWEEN 20®.

Host plants are sprayed with test solution, dried and inoculated with fungi. When disease symptom development is optimal, the plants are rated for disease control according to the rating scale shown below. Each test contains inoculated treated plants, inoculated untreated plants and and a reference standard. When more than one test is run, the data are averaged. The data obtained are shown in Table V1a.

    ______________________________________                                         RATING SCALE                                                                   Rating      Range % Control                                                    ______________________________________                                         0            0                                                                 1            1-14                                                              2           15-29                                                              3           30-44                                                              4           45-59                                                              5           60-74                                                              6           75-89                                                              7           90-95                                                              8           96-99                                                              9           100                                                                --          no evaluation                                                      ______________________________________                                    

    ______________________________________                                         PHYTOPATHOGENIC FUNGI                                                          Symbol Disease         Pathogen                                                ______________________________________                                         AS     Apple Scab      Venturis inaequalis                                     GDM    Grape Downy Mildew                                                                             Plasmopara viticola                                     PB     Pepper Botrytis Botrytis cinerea                                        RB     Rice Blast      Pyricularia oryzae                                      SBC    Sugar Beet Cercospora                                                                          Cercospora beticola                                     TEB    Tomato Early Blight                                                                            Alternaria solani                                       WBM    Wheat Powdery Mildew                                                                           Erysiphe graminis f. sp. tritici                        WSN    Wheat Blotch    Septoria nodorum                                        ______________________________________                                    

                  TABLE VIa                                                        ______________________________________                                         Comp. AS     GDM     PB   RB   SBC  TEB  WPM   WSN                             ______________________________________                                         187   4      5       7    0    5    6    9     7                               188   5      0       5    0    4    0    8     6                               192   7      6       8    0    7    4    7     7                               193   6      8       7    0    6    2    8     3                               194   6      7       4    0    8    3    7     7                               195   6      5       5    7    7    0    7     7                               196   5      5       5    6    8    0    9     7                               197   5      7       8    0    7    0    8     7                               198   6      6       7    0    8    6    8     8                               199   6      5       7    0    3    4    8     7                               200   7      5       8    0    8    0    8     8                               201   6      7       3    0    6    0    8     5                               202   6      5       7    0    7    0    8     5                               203   0      0       8    0    8    6    8     6                               204   0      0       8    0    7    6    7     6                               ______________________________________                                    

Evaluation of In Vitro Fungicidal Activity of Test Compounds

Test compounds are dissolved in acetone and dispersed into cell well plates containing a suspension of ground fungal mycelium in a nutrient broth. Assay plates are incubated for 3-4 days at 21° C. Growth inhibition is measured visually and is rated using the following scale:

    ______________________________________                                                Rating                                                                               % Inhibition                                                      ______________________________________                                                0      0                                                                       1      1-29                                                                    3     30-59                                                                    5     60-89                                                                    7     90-99                                                                    9     100                                                               ______________________________________                                    

Untreated controls, solvent blanks and reference standards are included in each test. Assay fungi include the following pathogens:

    ______________________________________                                         SYMBOL     PATHOGEN                                                            ______________________________________                                         FUS OXC    Fusarium oxysporium f. sp. cucumerinum                              PSDC HE    Pseudocercosporella herpotrichoides                                 PTYH UL    Pythium ultimum                                                     RHIZ SO    Rhizoctonia solani                                                  FUS     PSDC           PYTH    RHIZ                                            OXC     HE             UL      SO                                              ______________________________________                                         0       7              5       5                                               0       0              7       5                                               0       0              7       5                                               0       0              7       3                                               0       5              7       7                                               0       0              7       3                                               0       0              7       7                                               0       0              7       7                                               1       7              7       7                                               0       0              3       3                                               0       5              7       7                                               0       5              7       7                                               0       7              7       7                                               0       0              1       3                                               0       1              0       1                                               ______________________________________                                     

I claim:
 1. A compound of the general formula I, ##STR8## or an acid-addition salt thereof, in which R¹ or each R¹ independently represents an optionally substituted alkyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkylalkyl, an optionally substituted alkoxy, an optionally substituted cycloalkoxy, an optionally substituted alkoxyalkyl, an optionally substituted aralkyl, an optionally substituted aryl or an optionally substituted aryloxy group, or R¹ or each R¹, together with the ring to which they are attached, represents an optionally substituted polycyclic hydrocarbyl group,R² represents a hydrogen atom or a C₁₋₁₄ alkyl group, R³ represents a hydrogen atom, a hydroxy group or an optionally substituted alkoxy or an optionally substituted acyloxy group, R⁴ and R⁵ each independently represents a hydrogen atom, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkylalkyl, an optionally substituted cycloalkyl, an optionally substituted bicycloalkyl, an optionally substituted tricycloalkyl, an optionally substituted alkoxyalkyl, an optionally substituted aryl, an optionally substituted aralkyl, an optionally substituted 4- to 6-membered heterocyclyl, an optionally substituted tetrahydrofurfuryl or an optionally substituted dioxolanyl group, or R⁴ and R⁵ together represent an optionally substituted, saturated or unsaturated carbon chain which may optionally contain one or more oxygen atoms and which may optionally be aryl- or cycloalkyl fused, m represents zero or an integer from 1 to 6, and p represents zero.
 2. A compound according to claim 1, in which any alkyl part of any of the groupsR¹ to R⁵ contains up to 10 carbon atoms, any alkenyl or alkynyl part of any of the substituents R¹ to R⁵ contains from 3 to 8 carbon atoms, any bicyclic part of the groups R1 to R⁵ contains 6 to 12 carbon atoms, any tricyclic part of the groups R¹ to R⁵ contains from 8 to 14 carbon atoms, any polycyclic part of the groups R¹ to R⁵ contains from 6 to 20 carbon atoms, any chain, especially any carbon chain, contains from 4 to 6 carbon atoms and any aryl part of the substituents R¹ and R⁵ contain 6 or 10 carbon atoms and in which each optionally substituted group independently is substituted by one or more halogen atoms or nitro, cyano, C₁₋₆ alkyl, C₃₋₆ cycloalkyl, C₃₋₆ cycloalkenyl, C₁₋₆ haloalkyl, C₃₋₆ halocycloalkyl, C₁₋₆ alkoxy, C₁₋₆ haloalkoxy, phenyl, halo- or dihalo-phenyl or pyridyl groups.
 3. A compound according to claim 2, in which R¹ or each R¹ independently represents a C₁₋₁₀ alkyl, C₃₋₆ cycloalkyl, C₃₋₈ cycloalkyl-C₁₋₆ alkyl, C₁₋₆ alkoxy, C₁₋₁₀ alkoxy-C₁₋₆ alkyl or phenyl group, or one or more groups R¹ together with the ring to which they are attached, represent a C₈₋₁₂ bicyclic, C₉₋₁₄ tricyclic or C₉₋₁₆ quadricyclic hydrocarbyl group, each of the above groups optionally substituted by one or more halogen atoms, C₁₋₄ alkyl, C₁₋₄ haloalkyl or C₁₋₁₄ alkoxy groups.
 4. A compounds according to claim 3, in which R¹ or each R¹ independently represents a C₁₋₈ alkyl group.
 5. A compound according to claim 1, in which m represents
 1. 6. A compound according to claim 5, in which the substituent R² is attached to the 4-position of the cychlohexyl ring.
 7. A compound according to claim 1, in which R² represents a hydrogen atom.
 8. A compound according to claim 1, in which R³ represents a hydrogen atom.
 9. A compound according to claim 1, in which R⁴ and R⁵ each independently represent a hydrogen atom, a C₁₋₂₀ alkyl, C₂₋₆ alkynyl, C₂₋₆ alkynyl, C₃₋₈ cycloalkyl-C₁₋₆ alkyl, C₃₋₈ cycloalkyl, C₆₋₁₀ bicycloalkyl, C₈₋₁₄ tricycloalkyl, phenyl, phenyl-C₁₋₆ alkyl, halophenyl-C₁₋₆ alkyl or pyridyl-C₁₋₆ alkyl group, or R⁴ and R⁵ together represent a saturated carbon chain containing three to eight carbon atoms while optionally one or more additional oxygen atoms may be present in the chain and which chain may optionally be aryl- or cycloalkyl-fused, each of the above groups optionally substituted by one or more halogen atoms, C₁₋₆ cycloalkenyl, C₁₋₄ alkyl, C₁₋₄ haloalkyl or C₁₋₄ alkoxy.
 10. A compound according to claim 9, in which R⁴ and R⁵ each independently represent a hydrogen atom, A C₂₋₁₂ alkyl, C₂₋₅ alkenyl, C₅₋₇ cyclo-C₁₋₂ alkyl group, or R⁴ and R⁵ together represent a saturated chain containing four or five carbon atoms while optionally additional oxygen atoms may be present and which chain optionally may be aryl- or cyclopentyl fused, each of the above groups optionally substituted by one or more chlorine or fluorine atoms or C₁₋₄ alkyl, C₁₋₄ haloalkyl, C₄₋₆ cycloalkenyl or C₁₋₄ alkoxy groups. 